GO Annotations Graph

• Symbol: Rasgrp1
• Name: RAS guanyl releasing protein 1
• ID: MGI:1314635

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0019992	diacylglycerol binding	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031210	phosphatidylcholine binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1169494
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730865
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1169494
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0090630	activation of GTPase activity	IMP	J:65115
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:164563
Biological Process	GO:0090630	activation of GTPase activity	IMP	J:125310
Biological Process	GO:0042113	B cell activation	ISO	J:164563
Biological Process	GO:0042100	B cell proliferation	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	IMP	J:125310
Biological Process	GO:0032762	mast cell cytokine production	IMP	J:125310
Biological Process	GO:0043303	mast cell degranulation	IMP	J:125310
Biological Process	GO:0030101	natural killer cell activation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IMP	J:179434
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	IMP	J:179434
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	IMP	J:65115
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	IMP	J:125310
Biological Process	GO:0032252	secretory granule localization	IMP	J:125310
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0042110	T cell activation	ISO	J:164563
Biological Process	GO:0042098	T cell proliferation	ISO	J:164563
Biological Process	GO:0047496	vesicle transport along microtubule	IMP	J:125310