GO Annotations Graph

• Symbol: Casq2
• Name: calsequestrin 2
• ID: MGI:1309469

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IMP	J:114621
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0140314	calcium ion sequestering activity	ISO	J:164563
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:164563
Molecular Function	GO:0043167	ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:159954
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	TAS	J:72636
Cellular Component	GO:0033018	sarcoplasmic reticulum lumen	IDA	J:159954
Cellular Component	GO:0033018	sarcoplasmic reticulum lumen	IBA	J:265628
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:149895
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0071313	cellular response to caffeine	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	IDA	J:186034
Biological Process	GO:0043267	negative regulation of potassium ion transport	IDA	J:186034
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	ISO	J:155856
Biological Process	GO:0051258	protein polymerization	ISO	J:164563
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO	J:155856
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO	J:164563
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP	J:114621
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IBA	J:265628
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IDA	J:46786
Biological Process	GO:0010649	regulation of cell communication by electrical coupling	ISO	J:164563
Biological Process	GO:0002027	regulation of heart rate	IMP	J:114621
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0060306	regulation of membrane repolarization	IDA	J:186034
Biological Process	GO:0006937	regulation of muscle contraction	TAS	J:72636
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:114621
Biological Process	GO:0045214	sarcomere organization	IMP	J:159954
Biological Process	GO:0051208	sequestering of calcium ion	ISO	J:164563
Biological Process	GO:0051238	sequestering of metal ion	ISO	J:164563