GO Annotations Graph

• Symbol: F2rl2
• Name: coagulation factor II thrombin receptor like 2
• ID: MGI:1298208

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IBA	J:265628
Molecular Function	GO:0005096	GTPase activator activity	IGI	J:329322
Molecular Function	GO:0001648	proteinase-activated receptor activity	IGI	J:329322
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:329322
Molecular Function	GO:0015057	thrombin-activated receptor activity	IEA	J:72247
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:113146
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0007596	blood coagulation	IEA	J:60000
Biological Process	GO:0007596	blood coagulation	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IDA	J:329322
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	IGI	J:329322
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IDA	J:329322
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	IGI	J:329322
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	J:265628
Biological Process	GO:0032024	positive regulation of insulin secretion	IGI	J:329322
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:329322
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway	IEA	J:72247