Cdk6 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cdk6
cyclin dependent kinase 6
MGI:1277162

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:155856
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	IBA	J:265628
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0098770	FBXO family protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IDA	J:174697
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201595
Molecular Function	GO:0005515	protein binding	IPI	J:192031
Molecular Function	GO:0005515	protein binding	IPI	J:171849
Molecular Function	GO:0005515	protein binding	IPI	J:183053
Molecular Function	GO:0005515	protein binding	IPI	J:28319
Molecular Function	GO:0005515	protein binding	IPI	J:183053
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0097132	cyclin D2-CDK6 complex	IDA	J:24521
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0043697	cell dedifferentiation	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0044838	cell quiescence	IMP	J:220783
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0042063	gliogenesis	ISO	J:164563
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:174697
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:174697
Biological Process	GO:0060218	hematopoietic stem cell differentiation	IMP	J:174697
Biological Process	GO:0060218	hematopoietic stem cell differentiation	IMP	J:174697
Biological Process	GO:0030097	hemopoiesis	IMP	J:92529
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:164563
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0045656	negative regulation of monocyte differentiation	ISO	J:164563
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:220783
Biological Process	GO:0007219	Notch signaling pathway	IGI	J:174697
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:174697
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:174697
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IEA	J:72247
Biological Process	GO:0045646	regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	IMP	J:220783
Biological Process	GO:0036275	response to 5-fluorouracil	IMP	J:220783
Biological Process	GO:0010033	response to organic substance	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:174697
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:174697
Biological Process	GO:0003323	type B pancreatic cell development	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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