Smad3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smad3
SMAD family member 3
MGI:1201674

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	ISO	J:155856
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:114818
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:117514
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0070410	co-SMAD binding	ISO	J:164563
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0005518	collagen binding	IPI	J:86396
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:322376
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IPI	J:261825
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:85559
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:94649
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:183041
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding	ISO	J:164563
Molecular Function	GO:0031962	nuclear mineralocorticoid receptor binding	ISO	J:164563
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:141299
Molecular Function	GO:0005515	protein binding	IPI	J:169049
Molecular Function	GO:0005515	protein binding	IPI	J:140377
Molecular Function	GO:0005515	protein binding	IPI	J:117514
Molecular Function	GO:0005515	protein binding	IPI	J:143960
Molecular Function	GO:0005515	protein binding	IPI	J:180221
Molecular Function	GO:0005515	protein binding	IPI	J:200480
Molecular Function	GO:0005515	protein binding	IPI	J:182366
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:183188
Molecular Function	GO:0005515	protein binding	IPI	J:72619
Molecular Function	GO:0005515	protein binding	IPI	J:81747
Molecular Function	GO:0005515	protein binding	IPI	J:178818
Molecular Function	GO:0005515	protein binding	IPI	J:114818
Molecular Function	GO:0005515	protein binding	IPI	J:89598
Molecular Function	GO:0005515	protein binding	IPI	J:93135
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:89598
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:94649
Molecular Function	GO:0005515	protein binding	IPI	J:93345
Molecular Function	GO:0005515	protein binding	IPI	J:94649
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:109361
Molecular Function	GO:0005515	protein binding	IPI	J:122807
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:224716
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:154847
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0032810	sterol response element binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:172903
Cellular Component	GO:0005737	cytoplasm	IDA	J:169049
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9605444
Cellular Component	GO:0071144	heteromeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0005637	nuclear inner membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9717136
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9754488
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756720
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756964
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9625492
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:172903
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:169049
Cellular Component	GO:0005634	nucleus	IDA	J:85559
Cellular Component	GO:0005634	nucleus	IDA	J:94649
Cellular Component	GO:0005886	plasma membrane	IDA	J:81747
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0071141	SMAD protein complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030325	adrenal gland development	ISO	J:155856
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0045216	cell-cell junction organization	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IDA	J:141299
Biological Process	GO:0048589	developmental growth	IGI	J:106308
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:106308
Biological Process	GO:0048617	embryonic foregut morphogenesis	IGI	J:106308
Biological Process	GO:0009880	embryonic pattern specification	IGI	J:106308
Biological Process	GO:0007492	endoderm development	IGI	J:106308
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0007369	gastrulation	IGI	J:106308
Biological Process	GO:0001947	heart looping	IGI	J:106308
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0002520	immune system development	IGI	J:106308
Biological Process	GO:0001701	in utero embryonic development	IGI	J:106308
Biological Process	GO:0007254	JNK cascade	IMP	J:141299
Biological Process	GO:0070306	lens fiber cell differentiation	IMP	J:124023
Biological Process	GO:0001889	liver development	IGI	J:106308
Biological Process	GO:0000165	MAPK cascade	IMP	J:141299
Biological Process	GO:0001707	mesoderm formation	IMP	J:89189
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	ISO	J:155856
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:59673
Biological Process	GO:0061767	negative regulation of lung blood pressure	ISO	J:155856
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IGI	J:93345
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	IMP	J:175326
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:48930
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:72619
Biological Process	GO:0061045	negative regulation of wound healing	IMP	J:59673
Biological Process	GO:0061045	negative regulation of wound healing	IMP	J:175198
Biological Process	GO:0061045	negative regulation of wound healing	IMP	J:175326
Biological Process	GO:0038092	nodal signaling pathway	ISO	J:164563
Biological Process	GO:0002076	osteoblast development	IGI	J:93345
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:111518
Biological Process	GO:0048340	paraxial mesoderm morphogenesis	IMP	J:89189
Biological Process	GO:0060039	pericardium development	IGI	J:106308
Biological Process	GO:0010694	positive regulation of alkaline phosphatase activity	ISO	J:155856
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:155856
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:175326
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:94649
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:93135
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:1901203	positive regulation of extracellular matrix assembly	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0050927	positive regulation of positive chemotaxis	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:224716
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:141299
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:114818
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:93345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:195995
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:85559
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:110800
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:93345
Biological Process	GO:0032916	positive regulation of transforming growth factor beta3 production	ISO	J:155856
Biological Process	GO:0050821	protein stabilization	ISO	J:155856
Biological Process	GO:0051098	regulation of binding	IDA	J:94649
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:105918
Biological Process	GO:0050776	regulation of immune response	IMP	J:53510
Biological Process	GO:0016202	regulation of striated muscle tissue development	IDA	J:72619
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	IDA	J:72619
Biological Process	GO:0032909	regulation of transforming growth factor beta2 production	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	ISO	J:155856
Biological Process	GO:0001501	skeletal system development	IGI	J:106308
Biological Process	GO:0007183	SMAD protein complex assembly	ISO	J:164563
Biological Process	GO:0007183	SMAD protein complex assembly	ISO	J:155856
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0060395	SMAD protein signal transduction	IGI	J:195995
Biological Process	GO:0001756	somitogenesis	IMP	J:106308
Biological Process	GO:0042110	T cell activation	IMP	J:53510
Biological Process	GO:0030878	thyroid gland development	IGI	J:106308
Biological Process	GO:0006366	transcription by RNA polymerase II	TAS	J:159086
Biological Process	GO:0060290	transdifferentiation	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:114818
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:93750
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:178818
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:93750
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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