GO Annotations Graph

• Symbol: Pla2g4a
• Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
• ID: MGI:1195256

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	ISO	J:155856
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	ISO	J:164563
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	IMP	J:39681
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	IBA	J:265628
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	ISO	J:164563
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	IBA	J:265628
Molecular Function	GO:0047499	calcium-independent phospholipase A2 activity	ISO	J:164563
Molecular Function	GO:1902387	ceramide 1-phosphate binding	ISO	J:164563
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0004622	lysophospholipase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008374	O-acyltransferase activity	ISO	J:164563
Molecular Function	GO:0102545	phosphatidyl phospholipase B activity	IEA	J:72245
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding	ISO	J:164563
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	ISO	J:164563
Molecular Function	GO:0010314	phosphatidylinositol-5-phosphate binding	ISO	J:164563
Molecular Function	GO:0004623	phospholipase A2 activity	IDA	J:178284
Molecular Function	GO:0004623	phospholipase A2 activity	ISO	J:164563
Molecular Function	GO:0004620	phospholipase activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:178284
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:121157
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:121157
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:121157
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0042588	zymogen granule	ISO	J:155856
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:155856
Biological Process	GO:0050482	arachidonic acid secretion	IDA	J:178284
Biological Process	GO:0050482	arachidonic acid secretion	IMP	J:121157
Biological Process	GO:0071236	cellular response to antibiotic	IDA	J:121157
Biological Process	GO:0046697	decidualization	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:121157
Biological Process	GO:0006633	fatty acid biosynthetic process	IEA	J:60000
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0006071	glycerol metabolic process	IEA	J:60000
Biological Process	GO:0046475	glycerophospholipid catabolic process	IBA	J:265628
Biological Process	GO:0046456	icosanoid biosynthetic process	IMP	J:121157
Biological Process	GO:0019370	leukotriene biosynthetic process	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	IMP	J:39681
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006640	monoacylglycerol biosynthetic process	ISO	J:164563
Biological Process	GO:0001542	ovulation from ovarian follicle	ISO	J:155856
Biological Process	GO:0036151	phosphatidylcholine acyl-chain remodeling	ISO	J:164563
Biological Process	GO:0034638	phosphatidylcholine catabolic process	ISO	J:164563
Biological Process	GO:0034638	phosphatidylcholine catabolic process	IMP	J:39681
Biological Process	GO:0034478	phosphatidylglycerol catabolic process	ISO	J:164563
Biological Process	GO:0009395	phospholipid catabolic process	IEA	J:72247
Biological Process	GO:0009395	phospholipid catabolic process	IEA	J:60000
Biological Process	GO:0006663	platelet activating factor biosynthetic process	IMP	J:39254
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:39681
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:39254
Biological Process	GO:0010572	positive regulation of platelet activation	ISO	J:164563
Biological Process	GO:0031394	positive regulation of prostaglandin biosynthetic process	ISO	J:155856
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	IMP	J:232433
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IMP	J:107430
Biological Process	GO:0031340	positive regulation of vesicle fusion	ISO	J:155856
Biological Process	GO:0001516	prostaglandin biosynthetic process	ISO	J:164563
Biological Process	GO:0001516	prostaglandin biosynthetic process	IMP	J:39254
Biological Process	GO:0001516	prostaglandin biosynthetic process	IMP	J:39681
Biological Process	GO:0006693	prostaglandin metabolic process	IEA	J:60000
Biological Process	GO:0042127	regulation of cell population proliferation	IGI	J:65510
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0043129	surfactant homeostasis	ISO	J:155856