GO Annotations Graph

• Symbol: Ece1
• Name: endothelin converting enzyme 1
• ID: MGI:1101357

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	ISS	J:40232
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISS	J:40232
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISS	J:40232
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Cellular Component	GO:0033093	Weibel-Palade body	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0060385	axonogenesis involved in innervation	IMP	J:274700
Biological Process	GO:0097746	blood vessel diameter maintenance	ISO	J:155856
Biological Process	GO:0010815	bradykinin catabolic process	ISO	J:164563
Biological Process	GO:0010816	calcitonin catabolic process	ISO	J:164563
Biological Process	GO:0043583	ear development	ISO	J:164563
Biological Process	GO:0042733	embryonic digit morphogenesis	ISO	J:164563
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:274700
Biological Process	GO:0034959	endothelin maturation	ISO	J:164563
Biological Process	GO:0010467	gene expression	IMP	J:274700
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0042447	hormone catabolic process	ISO	J:164563
Biological Process	GO:0031175	neuron projection development	IMP	J:250662
Biological Process	GO:0016486	peptide hormone processing	ISO	J:164563
Biological Process	GO:0016486	peptide hormone processing	IBA	J:265628
Biological Process	GO:0016486	peptide hormone processing	ISS	J:40232
Biological Process	GO:0060037	pharyngeal system development	IMP	J:85487
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001921	positive regulation of receptor recycling	ISO	J:164563
Biological Process	GO:0001921	positive regulation of receptor recycling	ISO	J:155856
Biological Process	GO:0016485	protein processing	ISO	J:155856
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:274700
Biological Process	GO:0010814	substance P catabolic process	ISO	J:164563
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700
Biological Process	GO:0097492	sympathetic neuron axon guidance	IMP	J:274700