GO Annotations Graph

• Symbol: S1pr1
• Name: sphingosine-1-phosphate receptor 1
• ID: MGI:1096355

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:155856
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0046625	sphingolipid binding	ISO	J:155856
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	ISO	J:164563
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	IMP	J:71961
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	IBA	J:265628
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0009897	external side of plasma membrane	IMP	J:141431
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0031532	actin cytoskeleton reorganization	IMP	J:120048
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	J:71372
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IDA	J:93030
Biological Process	GO:0001955	blood vessel maturation	IMP	J:71961
Biological Process	GO:0007420	brain development	IMP	J:103755
Biological Process	GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis	IMP	J:173601
Biological Process	GO:0016477	cell migration	IMP	J:147106
Biological Process	GO:0008283	cell population proliferation	IMP	J:103755
Biological Process	GO:0006935	chemotaxis	IMP	J:71961
Biological Process	GO:0006935	chemotaxis	IMP	J:120048
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0061384	heart trabecula morphogenesis	IMP	J:173601
Biological Process	GO:0030032	lamellipodium assembly	IMP	J:120048
Biological Process	GO:0030595	leukocyte chemotaxis	IDA	J:219661
Biological Process	GO:0051497	negative regulation of stress fiber assembly	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:103755
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0050927	positive regulation of positive chemotaxis	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0030500	regulation of bone mineralization	IMP	J:147106
Biological Process	GO:0045124	regulation of bone resorption	IMP	J:147106
Biological Process	GO:0030155	regulation of cell adhesion	IDA	J:93030
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	ISO	J:164563
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	IMP	J:71961
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	IBA	J:265628
Biological Process	GO:0072678	T cell migration	IMP	J:89522