GO Annotations Graph

• Symbol: Wrn
• Name: Werner syndrome RecQ like helicase
• ID: MGI:109635

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043138	3'-5' DNA helicase activity	ISO	J:164563
Molecular Function	GO:0043138	3'-5' DNA helicase activity	IBA	J:265628
Molecular Function	GO:0008408	3'-5' exonuclease activity	ISO	J:73065
Molecular Function	GO:0008408	3'-5' exonuclease activity	IDA	J:62921
Molecular Function	GO:0070337	3'-flap-structured DNA binding	ISO	J:164563
Molecular Function	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0000405	bubble DNA binding	ISO	J:164563
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003678	DNA helicase activity	ISO	J:73065
Molecular Function	GO:0004527	exonuclease activity	ISO	J:73065
Molecular Function	GO:0061749	forked DNA-dependent helicase activity	ISO	J:164563
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:164563
Molecular Function	GO:0009378	four-way junction helicase activity	ISO	J:164563
Molecular Function	GO:0009378	four-way junction helicase activity	IBA	J:265628
Molecular Function	GO:0051880	G-quadruplex DNA binding	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	IEA	J:72247
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0030145	manganese ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0032405	MutLalpha complex binding	ISO	J:164563
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:69903
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0061821	telomeric D-loop binding	ISO	J:164563
Molecular Function	GO:0061849	telomeric G-quadruplex DNA binding	ISO	J:164563
Molecular Function	GO:0000403	Y-form DNA binding	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IBA	J:265628
Cellular Component	GO:0000781	chromosome, telomeric region	IMP	J:227293
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:73065
Cellular Component	GO:0005730	nucleolus	ISO	J:73065
Cellular Component	GO:0005730	nucleolus	ISO	J:69659
Cellular Component	GO:0005730	nucleolus	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	IBA	J:265628
Cellular Component	GO:0005654	nucleoplasm	ISO	J:69659
Cellular Component	GO:0005654	nucleoplasm	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	IDA	J:69659
Cellular Component	GO:0005654	nucleoplasm	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	IDA	J:69659
Cellular Component	GO:0005654	nucleoplasm	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:48424
Cellular Component	GO:0005657	replication fork	IMP	J:227293
Biological Process	GO:0006284	base-excision repair	ISO	J:164563
Biological Process	GO:0044237	cellular metabolic process	IEA	J:72247
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:164563
Biological Process	GO:0009267	cellular response to starvation	ISO	J:69659
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:91715
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0006259	DNA metabolic process	ISO	J:164563
Biological Process	GO:0006259	DNA metabolic process	IMP	J:73919
Biological Process	GO:0006259	DNA metabolic process	IMP	J:83068
Biological Process	GO:0006310	DNA recombination	IEA	J:72247
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006260	DNA replication	ISO	J:164563
Biological Process	GO:0006260	DNA replication	IGI	J:227293
Biological Process	GO:0006260	DNA replication	IMP	J:227293
Biological Process	GO:0006260	DNA replication	IMP	J:48424
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	ISO	J:164563
Biological Process	GO:0006268	DNA unwinding involved in DNA replication	IBA	J:265628
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0044806	G-quadruplex DNA unwinding	IGI	J:227293
Biological Process	GO:0044806	G-quadruplex DNA unwinding	IMP	J:227293
Biological Process	GO:0044806	G-quadruplex DNA unwinding	ISO	J:164563
Biological Process	GO:0044806	G-quadruplex DNA unwinding	IBA	J:265628
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0010259	multicellular organism aging	IBA	J:265628
Biological Process	GO:0006139	nucleobase-containing compound metabolic process	IEA	J:72247
Biological Process	GO:0051345	positive regulation of hydrolase activity	ISO	J:164563
Biological Process	GO:0098530	positive regulation of strand invasion	ISO	J:164563
Biological Process	GO:1902570	protein localization to nucleolus	ISO	J:69659
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:73065
Biological Process	GO:0040009	regulation of growth rate	IMP	J:83068
Biological Process	GO:0031297	replication fork processing	ISO	J:164563
Biological Process	GO:0090399	replicative senescence	IMP	J:61567
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0010225	response to UV-C	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	IGI	J:91715
Biological Process	GO:0000723	telomere maintenance	IGI	J:93016
Biological Process	GO:0000723	telomere maintenance	IGI	J:93016
Biological Process	GO:0000723	telomere maintenance	IMP	J:83068
Biological Process	GO:0000723	telomere maintenance	IGI	J:91715
Biological Process	GO:0061820	telomeric D-loop disassembly	ISO	J:164563