GO Annotations Graph

• Symbol: Adam10
• Name: a disintegrin and metallopeptidase domain 10
• ID: MGI:109548

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:273527
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:276414
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:283178
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:276403
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:84628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070573	metallodipeptidase activity	IMP	J:88801
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:155856
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	TAS	Reactome:R-MMU-2193065
Molecular Function	GO:0004222	metalloendopeptidase activity	TAS	Reactome:R-MMU-9604278
Molecular Function	GO:0004222	metalloendopeptidase activity	TAS	Reactome:R-NUL-209162
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	ISO	J:164563
Molecular Function	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:89492
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:94943
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:88801
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:121009
Molecular Function	GO:0008237	metallopeptidase activity	IMP	J:319902
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:325503
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:201438
Molecular Function	GO:0005515	protein binding	IPI	J:276403
Molecular Function	GO:0005515	protein binding	IPI	J:79740
Molecular Function	GO:0005515	protein binding	IPI	J:118332
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:79740
Molecular Function	GO:0019901	protein kinase binding	IDA	J:79740
Molecular Function	GO:0042169	SH2 domain binding	NAS	J:79740
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:256075
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0005737	cytoplasm	IDA	J:79740
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263409
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326644
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005798	Golgi-associated vesicle	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:79740
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:276403
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-179883
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2193065
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928661
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9604278
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-209162
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IMP	J:121009
Cellular Component	GO:0005886	plasma membrane	IMP	J:88801
Cellular Component	GO:0005886	plasma membrane	ISO	J:325503
Cellular Component	GO:0046930	pore complex	IMP	J:276415
Cellular Component	GO:0046930	pore complex	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:118332
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	IDA	J:201438
Cellular Component	GO:0097060	synaptic membrane	ISO	J:164563
Cellular Component	GO:0097060	synaptic membrane	IBA	J:265628
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0097197	tetraspanin-enriched microdomain	ISO	J:164563
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Biological Process	GO:0034332	adherens junction organization	IMP	J:276414
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0034205	amyloid-beta formation	ISO	J:155856
Biological Process	GO:0090102	cochlea development	IMP	J:276414
Biological Process	GO:0051089	constitutive protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0038004	epidermal growth factor receptor ligand maturation	IMP	J:121009
Biological Process	GO:0038004	epidermal growth factor receptor ligand maturation	IMP	J:88801
Biological Process	GO:0001701	in utero embryonic development	IMP	J:94943
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:276414
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:283178
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IDA	J:273527
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:276403
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:73065
Biological Process	GO:0042117	monocyte activation	ISO	J:164563
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0007220	Notch receptor processing	NAS	J:94943
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:94943
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0006913	nucleocytoplasmic transport	NAS	J:79740
Biological Process	GO:0046931	pore complex assembly	ISO	J:164563
Biological Process	GO:0046931	pore complex assembly	IMP	J:276415
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010820	positive regulation of T cell chemotaxis	ISO	J:164563
Biological Process	GO:0099173	postsynapse organization	IDA	J:263409
Biological Process	GO:0099173	postsynapse organization	IDA	J:263409
Biological Process	GO:0099173	postsynapse organization	EXP	J:263409
Biological Process	GO:0140249	protein catabolic process at postsynapse	IMP	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IDA	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IEP	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	EXP	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IDA	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IMP	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IDA	J:326644
Biological Process	GO:0006468	protein phosphorylation	IDA	J:79740
Biological Process	GO:0016485	protein processing	IDA	J:160170
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:263409
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP	J:263409
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:263409
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:263409
Biological Process	GO:0008593	regulation of Notch signaling pathway	IMP	J:276422
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IEP	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	EXP	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:326644
Biological Process	GO:1901342	regulation of vasculature development	IMP	J:276422
Biological Process	GO:1901342	regulation of vasculature development	IMP	J:276496
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:88801
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:319902
Biological Process	GO:0140448	signaling receptor ligand precursor processing	ISO	J:325503
Biological Process	GO:1901998	toxin transport	ISO	J:164563