Smad1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Smad1
SMAD family member 1
MGI:109452

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070410	co-SMAD binding	ISO	J:164563
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:86912
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:107396
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:299317
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:183041
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070878	primary miRNA binding	IDA	J:169047
Molecular Function	GO:0005515	protein binding	IPI	J:240376
Molecular Function	GO:0005515	protein binding	IPI	J:150837
Molecular Function	GO:0005515	protein binding	IPI	J:86912
Molecular Function	GO:0005515	protein binding	IPI	J:178818
Molecular Function	GO:0005515	protein binding	IPI	J:106994
Molecular Function	GO:0005515	protein binding	IPI	J:106994
Molecular Function	GO:0005515	protein binding	IPI	J:93345
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0005515	protein binding	IPI	J:95124
Molecular Function	GO:0005515	protein binding	IPI	J:170631
Molecular Function	GO:0005515	protein binding	IPI	J:79484
Molecular Function	GO:0005515	protein binding	IPI	J:152281
Molecular Function	GO:0005515	protein binding	IPI	J:211498
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:142136
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:240259
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:172903
Cellular Component	GO:0005737	cytoplasm	IDA	J:151027
Cellular Component	GO:0005737	cytoplasm	IDA	J:145723
Cellular Component	GO:0071144	heteromeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0071142	homomeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071142	homomeric SMAD protein complex	IPI	J:173440
Cellular Component	GO:0005637	nuclear inner membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:151027
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:116258
Cellular Component	GO:0005634	nucleus	IDA	J:299317
Cellular Component	GO:0005634	nucleus	IDA	J:217224
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:153961
Cellular Component	GO:0005634	nucleus	IDA	J:145723
Cellular Component	GO:0032991	protein-containing complex	ISO	J:198828
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:86912
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:196266
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:151027
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:155856
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:299317
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:109016
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:217224
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:90769
Biological Process	GO:0030509	BMP signaling pathway	TAS	J:79484
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:147287
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:109016
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:109016
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:147287
Biological Process	GO:0060348	bone development	IGI	J:147287
Biological Process	GO:0060348	bone development	IGI	J:147287
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:185712
Biological Process	GO:0060038	cardiac muscle cell proliferation	IGI	J:185712
Biological Process	GO:0051216	cartilage development	IGI	J:147287
Biological Process	GO:0051216	cartilage development	IGI	J:147287
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0008283	cell population proliferation	IMP	J:99098
Biological Process	GO:0071773	cellular response to BMP stimulus	IGI	J:196266
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:145723
Biological Process	GO:0006351	DNA-templated transcription	ISO	J:164563
Biological Process	GO:0007276	gamete generation	IMP	J:90769
Biological Process	GO:0030902	hindbrain development	IMP	J:99098
Biological Process	GO:0042592	homeostatic process	IMP	J:90769
Biological Process	GO:0006954	inflammatory response	IEP	J:116258
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	IMP	J:90769
Biological Process	GO:0001710	mesodermal cell fate commitment	IGI	J:111703
Biological Process	GO:0030901	midbrain development	IMP	J:99098
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:99098
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	IDA	J:299317
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	IDA	J:299402
Biological Process	GO:0002051	osteoblast fate commitment	IGI	J:93345
Biological Process	GO:0061036	positive regulation of cartilage development	IDA	J:149852
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:138571
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:169047
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:93345
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:107396
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:211498
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:144043
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:96487
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:149852
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IGI	J:196266
Biological Process	GO:0006468	protein phosphorylation	IDA	J:138769
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:80201
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:86912
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007183	SMAD protein complex assembly	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IGI	J:151027
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:144043
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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