GO Annotations Graph

• Symbol: Psen2
• Name: presenilin 2
• ID: MGI:109284

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IMP	J:84109
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IGI	J:168322
Molecular Function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	IMP	J:168322
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0004175	endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:122380
Molecular Function	GO:0004175	endopeptidase activity	IGI	J:126954
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:104643
Molecular Function	GO:0005515	protein binding	IPI	J:73169
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:93093
Molecular Function	GO:0005515	protein binding	IPI	J:104643
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0005938	cell cortex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0036064	ciliary basal body	IDA	J:173367
Cellular Component	GO:0035253	ciliary rootlet	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:46769
Cellular Component	GO:0043198	dendritic shaft	IBA	J:265628
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0070765	gamma-secretase complex	ISO	J:164563
Cellular Component	GO:0070765	gamma-secretase complex	IC	J:168322
Cellular Component	GO:0070765	gamma-secretase complex	IDA	J:84109
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:326644
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:326644
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0030426	growth cone	IBA	J:265628
Cellular Component	GO:0000776	kinetochore	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IDA	J:46769
Cellular Component	GO:0016020	membrane	IDA	J:84109
Cellular Component	GO:0016020	membrane	IDA	J:53093
Cellular Component	GO:0016020	membrane	IDA	J:100835
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0005743	mitochondrial inner membrane	IBA	J:265628
Cellular Component	GO:0031594	neuromuscular junction	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0043025	neuronal cell body	IDA	J:40990
Cellular Component	GO:0005637	nuclear inner membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-209285
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:104643
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:0042987	amyloid precursor protein catabolic process	IBA	J:265628
Biological Process	GO:0034205	amyloid-beta formation	ISO	J:164563
Biological Process	GO:0050435	amyloid-beta metabolic process	IBA	J:265628
Biological Process	GO:0050435	amyloid-beta metabolic process	IMP	J:84109
Biological Process	GO:0050435	amyloid-beta metabolic process	IDA	J:64511
Biological Process	GO:0042640	anagen	IGI	J:94517
Biological Process	GO:0097190	apoptotic signaling pathway	IGI	J:90685
Biological Process	GO:0097190	apoptotic signaling pathway	IGI	J:90685
Biological Process	GO:0048854	brain morphogenesis	IGI	J:125930
Biological Process	GO:0006816	calcium ion transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	IPI	J:104643
Biological Process	GO:0006816	calcium ion transport	IPI	J:104643
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:104643
Biological Process	GO:0001708	cell fate specification	IGI	J:94517
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IGI	J:58465
Biological Process	GO:0009790	embryo development	IGI	J:58465
Biological Process	GO:0009790	embryo development	IGI	J:58118
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:103603
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IGI	J:125448
Biological Process	GO:0030900	forebrain development	IGI	J:90685
Biological Process	GO:0001942	hair follicle development	IGI	J:58465
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IGI	J:115485
Biological Process	GO:0032635	interleukin-6 production	IGI	J:168322
Biological Process	GO:0032635	interleukin-6 production	IMP	J:168322
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0007611	learning or memory	IGI	J:89760
Biological Process	GO:0040011	locomotion	IGI	J:90685
Biological Process	GO:0048286	lung alveolus development	IMP	J:58118
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:168322
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:168322
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:0007613	memory	IGI	J:90685
Biological Process	GO:0007613	memory	IGI	J:125930
Biological Process	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	ISO	J:164563
Biological Process	GO:0002573	myeloid leukocyte differentiation	IGI	J:115485
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IGI	J:90685
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	IMP	J:168265
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IGI	J:90685
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:168265
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IMP	J:168265
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	IMP	J:168265
Biological Process	GO:0150076	neuroinflammatory response	IMP	J:168322
Biological Process	GO:0150076	neuroinflammatory response	IGI	J:168322
Biological Process	GO:0070050	neuron cellular homeostasis	IGI	J:218189
Biological Process	GO:0007220	Notch receptor processing	NAS	J:54336
Biological Process	GO:0007220	Notch receptor processing	IBA	J:265628
Biological Process	GO:0007219	Notch signaling pathway	IGI	J:126088
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:103603
Biological Process	GO:0043065	positive regulation of apoptotic process	IGI	J:103603
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0050820	positive regulation of coagulation	IMP	J:83641
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:37098
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:168265
Biological Process	GO:0001921	positive regulation of receptor recycling	IMP	J:168265
Biological Process	GO:0140249	protein catabolic process at postsynapse	IDA	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IDA	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IMP	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IDA	J:326644
Biological Process	GO:0140249	protein catabolic process at postsynapse	IEP	J:326644
Biological Process	GO:0051604	protein maturation	IGI	J:76858
Biological Process	GO:0019538	protein metabolic process	IGI	J:116653
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0016485	protein processing	IGI	J:92071
Biological Process	GO:0015031	protein transport	IGI	J:76858
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0110097	regulation of calcium import into the mitochondrion	ISO	J:164563
Biological Process	GO:0007176	regulation of epidermal growth factor-activated receptor activity	IGI	J:122380
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IEP	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:326644
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:326644
Biological Process	GO:0043393	regulation of protein binding	IGI	J:126954
Biological Process	GO:0048167	regulation of synaptic plasticity	IGI	J:89760
Biological Process	GO:0043589	skin morphogenesis	IMP	J:168265
Biological Process	GO:0001756	somitogenesis	IGI	J:154114
Biological Process	GO:0001756	somitogenesis	IGI	J:58465
Biological Process	GO:0002286	T cell activation involved in immune response	IGI	J:126088
Biological Process	GO:0050852	T cell receptor signaling pathway	IGI	J:126088
Biological Process	GO:0048538	thymus development	IGI	J:126088
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:168322
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:168322