GO Annotations Graph

• Symbol: Sirpa
• Name: signal-regulatory protein alpha
• ID: MGI:108563

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	ISO	J:164563
Molecular Function	GO:0030695	GTPase regulator activity	ISO	J:155856
Molecular Function	GO:1990405	protein antigen binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:75835
Molecular Function	GO:0005515	protein binding	IPI	J:86609
Molecular Function	GO:0005515	protein binding	IPI	J:86931
Molecular Function	GO:0005515	protein binding	IPI	J:84084
Molecular Function	GO:0086080	protein binding involved in heterotypic cell-cell adhesion	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0019903	protein phosphatase binding	IPI	J:126125
Molecular Function	GO:0045309	protein phosphorylated amino acid binding	IPI	J:80118
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-548971
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-548973
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:86609
Biological Process	GO:0007015	actin filament organization	IMP	J:79824
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0007160	cell-matrix adhesion	IMP	J:79824
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:155856
Biological Process	GO:0071349	cellular response to interleukin-12	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:126125
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:155856
Biological Process	GO:0007010	cytoskeleton organization	IMP	J:79824
Biological Process	GO:0097530	granulocyte migration	IGI	J:263441
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:202604
Biological Process	GO:0035696	monocyte extravasation	ISO	J:155856
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	IMP	J:126125
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IGI	J:263378
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:126125
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP	J:126125
Biological Process	GO:1903720	negative regulation of I-kappaB phosphorylation	IMP	J:126125
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032688	negative regulation of interferon-beta production	IMP	J:126125
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:126125
Biological Process	GO:0046329	negative regulation of JNK cascade	IMP	J:126125
Biological Process	GO:0071641	negative regulation of macrophage inflammatory protein 1 alpha production	IMP	J:126125
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	IMP	J:126125
Biological Process	GO:0050765	negative regulation of phagocytosis	ISO	J:155856
Biological Process	GO:0050765	negative regulation of phagocytosis	IMP	J:265610
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:126125
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:126125
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:126125
Biological Process	GO:0006911	phagocytosis, engulfment	IDA	J:86609
Biological Process	GO:0006910	phagocytosis, recognition	IDA	J:86609
Biological Process	GO:0050766	positive regulation of phagocytosis	IBA	J:265628
Biological Process	GO:0050766	positive regulation of phagocytosis	IDA	J:86609
Biological Process	GO:0050870	positive regulation of T cell activation	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0032651	regulation of interleukin-1 beta production	ISO	J:155856
Biological Process	GO:0032675	regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0032680	regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032680	regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0032649	regulation of type II interferon production	ISO	J:164563