GO Annotations Graph

• Symbol: Fzd6
• Name: frizzled class receptor 6
• ID: MGI:108474

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:140886
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	ISO	J:164563
Molecular Function	GO:0042813	Wnt receptor activity	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:164788
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	IPI	J:140886
Cellular Component	GO:0045177	apical part of cell	IDA	J:105752
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:225149
Cellular Component	GO:0016327	apicolateral plasma membrane	IDA	J:119451
Cellular Component	GO:0016327	apicolateral plasma membrane	IDA	J:119451
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:274568
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:274568
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-3965440
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0033278	cell proliferation in midbrain	IGI	J:155359
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0035880	embryonic nail plate morphogenesis	IMP	J:198837
Biological Process	GO:0048105	establishment of body hair planar orientation	IGI	J:228899
Biological Process	GO:0001736	establishment of planar polarity	IGI	J:105752
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0001942	hair follicle development	IMP	J:118253
Biological Process	GO:0001942	hair follicle development	IMP	J:91412
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:105752
Biological Process	GO:0030901	midbrain development	IGI	J:155359
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001843	neural tube closure	IGI	J:105752
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0030168	platelet activation	IMP	J:154748
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:72247
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	IDA	J:140886