GO Annotations Graph

• Symbol: Smad2
• Name: SMAD family member 2
• ID: MGI:108051

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:96056
Molecular Function	GO:0003682	chromatin binding	IDA	J:114818
Molecular Function	GO:0070410	co-SMAD binding	ISO	J:164563
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:322376
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IPI	J:261825
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:48930
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:94649
Molecular Function	GO:0070411	I-SMAD binding	ISO	J:164563
Molecular Function	GO:0070411	I-SMAD binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	IPI	J:183041
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:169049
Molecular Function	GO:0005515	protein binding	IPI	J:94649
Molecular Function	GO:0005515	protein binding	IPI	J:48930
Molecular Function	GO:0005515	protein binding	IPI	J:94649
Molecular Function	GO:0005515	protein binding	IPI	J:106894
Molecular Function	GO:0005515	protein binding	IPI	J:98125
Molecular Function	GO:0005515	protein binding	IPI	J:98125
Molecular Function	GO:0005515	protein binding	IPI	J:183041
Molecular Function	GO:0005515	protein binding	IPI	J:114818
Molecular Function	GO:0005515	protein binding	IPI	J:89598
Molecular Function	GO:0005515	protein binding	IPI	J:98125
Molecular Function	GO:0005515	protein binding	IPI	J:98125
Molecular Function	GO:0005515	protein binding	IPI	J:89598
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:154847
Molecular Function	GO:0046332	SMAD binding	IPI	J:172903
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0048156	tau protein binding	IDA	J:261825
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0032444	activin responsive factor complex	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:261825
Cellular Component	GO:0005737	cytoplasm	IDA	J:169049
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:87103
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0071144	heteromeric SMAD protein complex	IBA	J:265628
Cellular Component	GO:0071142	homomeric SMAD protein complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9717136
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9754488
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756720
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756964
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9625492
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:169049
Cellular Component	GO:0005634	nucleus	IDA	J:172903
Cellular Component	GO:0005634	nucleus	IDA	J:261825
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:87103
Cellular Component	GO:0005634	nucleus	IDA	J:169302
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0071141	SMAD protein complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:48930
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:123041
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0030325	adrenal gland development	ISO	J:155856
Biological Process	GO:0009653	anatomical structure morphogenesis	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:70006
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:46532
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:84300
Biological Process	GO:0003180	aortic valve morphogenesis	IGI	J:225399
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0045165	cell fate commitment	IMP	J:84300
Biological Process	GO:0007182	common-partner SMAD protein phosphorylation	ISO	J:119289
Biological Process	GO:0048589	developmental growth	IGI	J:106308
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:106308
Biological Process	GO:0048617	embryonic foregut morphogenesis	IGI	J:106308
Biological Process	GO:0009880	embryonic pattern specification	IGI	J:106308
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:225399
Biological Process	GO:0007492	endoderm development	IGI	J:106308
Biological Process	GO:0001706	endoderm formation	IMP	J:176969
Biological Process	GO:0007369	gastrulation	IGI	J:106308
Biological Process	GO:0007507	heart development	IGI	J:125512
Biological Process	GO:0001701	in utero embryonic development	IMP	J:125512
Biological Process	GO:0001701	in utero embryonic development	IGI	J:106308
Biological Process	GO:0030073	insulin secretion	IGI	J:125512
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:88288
Biological Process	GO:0030324	lung development	IGI	J:125512
Biological Process	GO:0001707	mesoderm formation	IMP	J:89189
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:191209
Biological Process	GO:0038092	nodal signaling pathway	ISO	J:164563
Biological Process	GO:0035265	organ growth	IGI	J:125512
Biological Process	GO:0031016	pancreas development	IGI	J:125512
Biological Process	GO:0048340	paraxial mesoderm morphogenesis	IMP	J:89189
Biological Process	GO:0007389	pattern specification process	IGI	J:125512
Biological Process	GO:0060039	pericardium development	IGI	J:106308
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:87103
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:94649
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP	J:87103
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:191209
Biological Process	GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:123041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:48930
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:195995
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:117465
Biological Process	GO:0009791	post-embryonic development	IGI	J:125512
Biological Process	GO:0006468	protein phosphorylation	ISS	J:119289
Biological Process	GO:0006468	protein phosphorylation	IDA	J:143910
Biological Process	GO:0003184	pulmonary valve morphogenesis	IGI	J:225399
Biological Process	GO:0051098	regulation of binding	IDA	J:94649
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0070723	response to cholesterol	ISO	J:164563
Biological Process	GO:0009749	response to glucose	IGI	J:125512
Biological Process	GO:0062009	secondary palate development	IMP	J:87103
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	ISO	J:155856
Biological Process	GO:0007183	SMAD protein complex assembly	ISO	J:164563
Biological Process	GO:0060395	SMAD protein signal transduction	IBA	J:265628
Biological Process	GO:0060395	SMAD protein signal transduction	IGI	J:195995
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:72786
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:136812
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:136812
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:88288
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:136812
Biological Process	GO:0001657	ureteric bud development	IEP	J:95433
Biological Process	GO:0007352	zygotic specification of dorsal/ventral axis	ISO	J:164563