GO Annotations Graph

• Symbol: Slc8a3
• Name: solute carrier family 8 (sodium/calcium exchanger), member 3
• ID: MGI:107976

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0015368	calcium:monoatomic cation antiporter activity	IDA	J:35796
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO	J:155856
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IMP	J:173357
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IMP	J:87615
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISO	J:155856
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IBA	J:265628
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0099580	monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential	IMP	J:173357
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0043679	axon terminus	IMP	J:271785
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:225481
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	IDA	J:225481
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:87615
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:225481
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IC	J:35796
Cellular Component	GO:0098794	postsynapse	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IMP	J:271785
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:87615
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:271785
Biological Process	GO:1990034	calcium ion export across plasma membrane	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:87615
Biological Process	GO:0070588	calcium ion transmembrane transport	IDA	J:35796
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:173357
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	IEA	J:72247
Biological Process	GO:0060402	calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0007154	cell communication	IEA	J:72247
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	IDA	J:225481
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	IMP	J:202604
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:271785
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:173357
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:87615
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0007612	learning	IMP	J:173357
Biological Process	GO:0007611	learning or memory	IMP	J:271785
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:173357
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:271785
Biological Process	GO:0007613	memory	IMP	J:173357
Biological Process	GO:0030001	metal ion transport	IDA	J:35796
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	IMP	J:225481
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	IMP	J:225481
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	IMP	J:271785
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0042552	myelination	IMP	J:203079
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	IMP	J:271785
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:203079
Biological Process	GO:0014819	regulation of skeletal muscle contraction	IMP	J:87615
Biological Process	GO:0035725	sodium ion transmembrane transport	IMP	J:87615
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0050808	synapse organization	IMP	J:271785
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247