Slc8a1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
MGI:107956

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030506	ankyrin binding	ISO	J:164563
Molecular Function	GO:0030506	ankyrin binding	IPI	J:166301
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:1905060	calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO	J:155856
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISO	J:164563
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISO	J:164563
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISO	J:155856
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IMP	J:65985
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IBA	J:265628
Molecular Function	GO:0005432	calcium:sodium antiporter activity	TAS	J:92483
Molecular Function	GO:0086038	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	TAS	J:152596
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0099580	monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:154829
Molecular Function	GO:0005515	protein binding	IPI	J:95157
Molecular Function	GO:0005515	protein binding	IPI	J:95157
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:166301
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0043679	axon terminus	IMP	J:271785
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:103213
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0014704	intercalated disc	ISO	J:155856
Cellular Component	GO:0016020	membrane	TAS	J:92483
Cellular Component	GO:0016020	membrane	IDA	J:110313
Cellular Component	GO:0005874	microtubule	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:167034
Cellular Component	GO:0005886	plasma membrane	IDA	J:102710
Cellular Component	GO:0098794	postsynapse	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IMP	J:271785
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:103813
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	IDA	J:95157
Cellular Component	GO:0045202	synapse	ISO	J:164563
Cellular Component	GO:0045202	synapse	IDA	J:271785
Cellular Component	GO:0030315	T-tubule	IDA	J:103813
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	IDA	J:182140
Cellular Component	GO:0030315	T-tubule	IDA	J:96039
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:1901660	calcium ion export	ISO	J:155856
Biological Process	GO:1901660	calcium ion export	IMP	J:65985
Biological Process	GO:1901660	calcium ion export	ISO	J:164563
Biological Process	GO:0055074	calcium ion homeostasis	IMP	J:65985
Biological Process	GO:0070509	calcium ion import	ISO	J:164563
Biological Process	GO:0070509	calcium ion import	IMP	J:65985
Biological Process	GO:0070509	calcium ion import	ISO	J:164563
Biological Process	GO:0070509	calcium ion import	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	IGI	J:220494
Biological Process	GO:0006816	calcium ion transport	IDA	J:54277
Biological Process	GO:0006816	calcium ion transport	TAS	J:92483
Biological Process	GO:0006816	calcium ion transport	IMP	J:102710
Biological Process	GO:0060402	calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0060402	calcium ion transport into cytosol	IMP	J:65985
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:65985
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:167034
Biological Process	GO:0060048	cardiac muscle contraction	IGI	J:101484
Biological Process	GO:0007154	cell communication	IEA	J:72247
Biological Process	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	ISO	J:155856
Biological Process	GO:0071313	cellular response to caffeine	IMP	J:65985
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:155856
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:155856
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:167034
Biological Process	GO:0001892	embryonic placenta development	IMP	J:167034
Biological Process	GO:0003007	heart morphogenesis	IGI	J:101484
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0006883	intracellular sodium ion homeostasis	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0055001	muscle cell development	IGI	J:101484
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	IMP	J:65985
Biological Process	GO:0071901	negative regulation of protein serine/threonine kinase activity	IMP	J:271785
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0098735	positive regulation of the force of heart contraction	ISO	J:164563
Biological Process	GO:0009791	post-embryonic development	IGI	J:101484
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	TAS	J:152596
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:271785
Biological Process	GO:0002027	regulation of heart rate	IMP	J:65985
Biological Process	GO:0002028	regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0002026	regulation of the force of heart contraction	IMP	J:102710
Biological Process	GO:0044557	relaxation of smooth muscle	IMP	J:65985
Biological Process	GO:0033198	response to ATP	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0035994	response to muscle stretch	ISO	J:164563
Biological Process	GO:0036376	sodium ion export across plasma membrane	IMP	J:65985
Biological Process	GO:0036376	sodium ion export across plasma membrane	ISO	J:155856
Biological Process	GO:0036376	sodium ion export across plasma membrane	ISO	J:164563
Biological Process	GO:0098719	sodium ion import across plasma membrane	IMP	J:65985
Biological Process	GO:0098719	sodium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0098719	sodium ion import across plasma membrane	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	ISO	J:155856
Biological Process	GO:0006814	sodium ion transport	IDA	J:54277
Biological Process	GO:0006814	sodium ion transport	TAS	J:92483
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0014829	vascular associated smooth muscle contraction	IMP	J:65985

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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