GO Annotations Graph

• Symbol: Serpina5
• Name: serine (or cysteine) peptidase inhibitor, clade A, member 5
• ID: MGI:107817

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0032190	acrosin binding	ISO	J:164563
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA	J:60000
Molecular Function	GO:0031210	phosphatidylcholine binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:94483
Molecular Function	GO:0001972	retinoic acid binding	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA	J:265628
Cellular Component	GO:0002080	acrosomal membrane	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0031091	platelet alpha granule	ISO	J:164563
Cellular Component	GO:0031094	platelet dense tubular network	ISO	J:164563
Cellular Component	GO:0097181	protein C inhibitor-coagulation factor V complex	ISO	J:164563
Cellular Component	GO:0097182	protein C inhibitor-coagulation factor Xa complex	ISO	J:164563
Cellular Component	GO:0097183	protein C inhibitor-coagulation factor XI complex	ISO	J:164563
Cellular Component	GO:0036029	protein C inhibitor-KLK3 complex	ISO	J:164563
Cellular Component	GO:0036030	protein C inhibitor-plasma kallikrein complex	ISO	J:164563
Cellular Component	GO:0036026	protein C inhibitor-PLAT complex	ISO	J:164563
Cellular Component	GO:0036027	protein C inhibitor-PLAU complex	ISO	J:164563
Cellular Component	GO:0036028	protein C inhibitor-thrombin complex	ISO	J:164563
Cellular Component	GO:0036025	protein C inhibitor-TMPRSS11E complex	ISO	J:164563
Cellular Component	GO:0036024	protein C inhibitor-TMPRSS7 complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IBA	J:265628
Biological Process	GO:0051346	negative regulation of hydrolase activity	ISO	J:164563
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA	J:60000
Biological Process	GO:0045861	negative regulation of proteolysis	ISO	J:155856
Biological Process	GO:0007283	spermatogenesis	IMP	J:66422