GO Annotations Graph

• Symbol: Irgm1
• Name: immunity-related GTPase family M member 1
• ID: MGI:107567

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051434	BH3 domain binding	ISO	J:164563
Molecular Function	GO:0050700	CARD domain binding	ISO	J:164563
Molecular Function	GO:1901612	cardiolipin binding	IDA	J:151541
Molecular Function	GO:1901612	cardiolipin binding	ISO	J:164563
Molecular Function	GO:0003925	G protein activity	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IEA	J:72247
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	IDA	J:151541
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IDA	J:151541
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IDA	J:151541
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	ISO	J:164563
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Cellular Component	GO:0044754	autolysosome	IDA	J:112322
Cellular Component	GO:0005776	autophagosome	IDA	J:112322
Cellular Component	GO:0000421	autophagosome membrane	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	TAS	J:87535
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	IDA	J:332984
Cellular Component	GO:0005770	late endosome	IDA	J:157238
Cellular Component	GO:0005770	late endosome	IDA	J:112322
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:332981
Cellular Component	GO:0005764	lysosome	IDA	J:157238
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:332984
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:143718
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0000045	autophagosome assembly	ISO	J:164563
Biological Process	GO:0000045	autophagosome assembly	IDA	J:112322
Biological Process	GO:0097352	autophagosome maturation	IDA	J:176619
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0061762	CAMKK-AMPK signaling cascade	ISO	J:164563
Biological Process	GO:0035458	cellular response to interferon-beta	IBA	J:265628
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:143718
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0006952	defense response	IMP	J:87535
Biological Process	GO:0042742	defense response to bacterium	IDA	J:151541
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IMP	J:112322
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IDA	J:151541
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0160049	negative regulation of cGAS/STING signaling pathway	ISO	J:164563
Biological Process	GO:0050687	negative regulation of defense response to virus	IMP	J:332983
Biological Process	GO:0050687	negative regulation of defense response to virus	ISO	J:164563
Biological Process	GO:1902034	negative regulation of hematopoietic stem cell proliferation	IMP	J:176943
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:305209
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	IDA	J:271759
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0032480	negative regulation of type I interferon production	IMP	J:305209
Biological Process	GO:0032480	negative regulation of type I interferon production	IMP	J:176943
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:142840
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO	J:164563
Biological Process	GO:1901098	positive regulation of autophagosome maturation	ISO	J:164563
Biological Process	GO:1901098	positive regulation of autophagosome maturation	IDA	J:112322
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:151541
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:112322
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:329066
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	IDA	J:332984
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:142840
Biological Process	GO:1905673	positive regulation of lysosome organization	ISO	J:164563
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:243244
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:318620
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:1901526	positive regulation of mitophagy	ISO	J:164563
Biological Process	GO:1901526	positive regulation of mitophagy	ISO	J:164563
Biological Process	GO:1901526	positive regulation of mitophagy	IMP	J:305209
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	IMP	J:112322
Biological Process	GO:1904417	positive regulation of xenophagy	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0061739	protein lipidation involved in autophagosome assembly	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0071211	protein targeting to vacuole involved in autophagy	ISO	J:164563
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0090140	regulation of mitochondrial fission	IDA	J:332984
Biological Process	GO:0061635	regulation of protein complex stability	ISO	J:164563
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0061912	selective autophagy	IDA	J:332981