Ppp3ca GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
MGI:107164

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	TAS	Reactome:R-MMU-2025936
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IDA	J:257321
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	ISO	J:155856
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	ISO	J:164563
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	IDA	J:257321
Molecular Function	GO:0033192	calmodulin-dependent protein phosphatase activity	IBA	J:265628
Molecular Function	GO:0016018	cyclosporin A binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0017018	myosin phosphatase activity	IEA	J:72245
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	ISO	J:155856
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IDA	J:100019
Molecular Function	GO:0005515	protein binding	IPI	J:282598
Molecular Function	GO:0005515	protein binding	IPI	J:319680
Molecular Function	GO:0005515	protein binding	IPI	J:257321
Molecular Function	GO:0005515	protein binding	IPI	J:183831
Molecular Function	GO:0005515	protein binding	IPI	J:163320
Molecular Function	GO:0005515	protein binding	IPI	J:259128
Molecular Function	GO:0005515	protein binding	IPI	J:174325
Molecular Function	GO:0005515	protein binding	IPI	J:126237
Molecular Function	GO:0005515	protein binding	IPI	J:81920
Molecular Function	GO:0005515	protein binding	IPI	J:116445
Molecular Function	GO:0005515	protein binding	IPI	J:142163
Molecular Function	GO:0005515	protein binding	IPI	J:150410
Molecular Function	GO:0005515	protein binding	IPI	J:126237
Molecular Function	GO:0005515	protein binding	IPI	J:96468
Molecular Function	GO:0005515	protein binding	IPI	J:81920
Molecular Function	GO:0005515	protein binding	IPI	J:81920
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0005955	calcineurin complex	IDA	J:257321
Cellular Component	GO:0005955	calcineurin complex	ISO	J:164563
Cellular Component	GO:0005955	calcineurin complex	ISO	J:155856
Cellular Component	GO:0005955	calcineurin complex	NAS	J:320122
Cellular Component	GO:0005955	calcineurin complex	IBA	J:265628
Cellular Component	GO:0005955	calcineurin complex	IDA	J:126237
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:320150
Cellular Component	GO:0005737	cytoplasm	IDA	J:103832
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	NAS	J:320049
Cellular Component	GO:0005829	cytosol	NAS	J:319677
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2025936
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:126237
Cellular Component	GO:0043197	dendritic spine	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:130656
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:130656
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IDA	J:126237
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:126237
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098794	postsynapse	IMP	J:130656
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320050
Cellular Component	GO:0008287	protein serine/threonine phosphatase complex	NAS	J:320049
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:130656
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:130656
Cellular Component	GO:0036057	slit diaphragm	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:96468
Biological Process	GO:0097720	calcineurin-mediated signaling	ISO	J:164563
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	ISO	J:164563
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IBA	J:265628
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IDA	J:38327
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IGI	J:142475
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IDA	J:174325
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:46399
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IGI	J:142475
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IMP	J:46398
Biological Process	GO:0033173	calcineurin-NFAT signaling cascade	IDA	J:147774
Biological Process	GO:0006816	calcium ion transport	IMP	J:84257
Biological Process	GO:0019722	calcium-mediated signaling	IGI	J:150410
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	IGI	J:79608
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:194263
Biological Process	GO:0016311	dephosphorylation	IDA	J:100019
Biological Process	GO:0016311	dephosphorylation	IDA	J:81920
Biological Process	GO:0008544	epidermis development	IMP	J:159586
Biological Process	GO:0060079	excitatory postsynaptic potential	IGI	J:120963
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:84257
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:159586
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:54583
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:96807
Biological Process	GO:0033555	multicellular organismal response to stress	IDA	J:73985
Biological Process	GO:1905949	negative regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:0035562	negative regulation of chromatin binding	IMP	J:194263
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	IMP	J:194263
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:208305
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:208305
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0023057	negative regulation of signaling	IMP	J:319680
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0070262	peptidyl-serine dephosphorylation	ISO	J:164563
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IMP	J:71750
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:320049
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	NAS	J:319999
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	NAS	J:319981
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IGI	J:208305
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IGI	J:233562
Biological Process	GO:1903244	positive regulation of cardiac muscle hypertrophy in response to stress	IDA	J:149624
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:1905205	positive regulation of connective tissue replacement	IGI	J:233562
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA	J:197653
Biological Process	GO:0045807	positive regulation of endocytosis	IMP	J:242470
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:208305
Biological Process	GO:0090193	positive regulation of glomerulus development	IMP	J:93625
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:103832
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IMP	J:320150
Biological Process	GO:0046878	positive regulation of saliva secretion	IMP	J:169854
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:208305
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:215013
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:121907
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	NAS	J:319981
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:130656
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:130656
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:130656
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:130656
Biological Process	GO:0006470	protein dephosphorylation	IDA	J:257321
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:155856
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:150410
Biological Process	GO:0006470	protein dephosphorylation	IMP	J:288625
Biological Process	GO:0006606	protein import into nucleus	IMP	J:288625
Biological Process	GO:0006606	protein import into nucleus	IDA	J:73985
Biological Process	GO:0061006	regulation of cell proliferation involved in kidney morphogenesis	IMP	J:93625
Biological Process	GO:0097205	renal filtration	IMP	J:110350
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:110822
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:100019
Biological Process	GO:0014883	transition between fast and slow fiber	IDA	J:174325

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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