GO Annotations Graph

• Symbol: Rfx3
• Name: regulatory factor X, 3 (influences HLA class II expression)
• ID: MGI:106582

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:169647
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:156925
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:209144
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:153136
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:169647
Cellular Component	GO:0005634	nucleus	IEA	J:72247
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:169647
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0048469	cell maturation	IMP	J:169647
Biological Process	GO:0060271	cilium assembly	IMP	J:169647
Biological Process	GO:0060285	cilium-dependent cell motility	IMP	J:153136
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:89880
Biological Process	GO:0006351	DNA-templated transcription	IMP	J:153136
Biological Process	GO:0031018	endocrine pancreas development	IMP	J:122122
Biological Process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	IMP	J:89880
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:169647
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:169647
Biological Process	GO:2000078	positive regulation of type B pancreatic cell development	IMP	J:169647
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:89880
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:153136
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:122122
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:169647
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072560	type B pancreatic cell maturation	IMP	J:169647