Hes5 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hes5
hes family bHLH transcription factor 5
MGI:104876

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:73065
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:175435
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:175195
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2197579
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0048708	astrocyte differentiation	IDA	J:175195
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:139170
Biological Process	GO:0007420	brain development	IMP	J:119796
Biological Process	GO:0043010	camera-type eye development	IMP	J:119796
Biological Process	GO:0051216	cartilage development	IMP	J:175507
Biological Process	GO:0051216	cartilage development	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IGI	J:94391
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0048469	cell maturation	IGI	J:94391
Biological Process	GO:0022010	central nervous system myelination	IMP	J:119556
Biological Process	GO:0072049	comma-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0021861	forebrain radial glial cell differentiation	ISO	J:155856
Biological Process	GO:0021781	glial cell fate commitment	IMP	J:62537
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis	IEP	J:93145
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	IDA	J:82774
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:108846
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	ISO	J:155856
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IMP	J:70081
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:2000981	negative regulation of inner ear receptor cell differentiation	IMP	J:108846
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:160292
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:94391
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:160292
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IDA	J:82774
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IMP	J:119556
Biological Process	GO:2000974	negative regulation of pro-B cell differentiation	ISO	J:155856
Biological Process	GO:2000737	negative regulation of stem cell differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119556
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119556
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119556
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0021915	neural tube development	IGI	J:62024
Biological Process	GO:0030182	neuron differentiation	IMP	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:94391
Biological Process	GO:0030182	neuron differentiation	IGI	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:160292
Biological Process	GO:0030182	neuron differentiation	IGI	J:160292
Biological Process	GO:0097150	neuronal stem cell population maintenance	ISO	J:155856
Biological Process	GO:0097150	neuronal stem cell population maintenance	IMP	J:175113
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	NAS	J:93145
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:119796
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:218237
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:119556
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:119556
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:119556
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IGI	J:139170
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:108846
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:108846
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IDA	J:175195
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:175195
Biological Process	GO:0065003	protein-containing complex assembly	IDA	J:175195
Biological Process	GO:0045595	regulation of cell differentiation	IMP	J:131591
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0031641	regulation of myelination	IMP	J:119556
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:144373
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:144373
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:62024
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:62024
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072050	S-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:146198
Biological Process	GO:0072086	specification of loop of Henle identity	IEP	J:97734
Biological Process	GO:0021537	telencephalon development	IGI	J:160292
Biological Process	GO:0021537	telencephalon development	IGI	J:139170
Biological Process	GO:0021537	telencephalon development	IGI	J:160292

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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