GO Annotations Graph

• Symbol: Lta
• Name: lymphotoxin A
• ID: MGI:104797

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:87393
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:39746
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:4753
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:47428
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:42508
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:43602
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:56996
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	TAS	J:17976
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5668798
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IGI	J:115034
Biological Process	GO:0006959	humoral immune response	IMP	J:28061
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	TAS	J:47428
Biological Process	GO:0006954	inflammatory response	TAS	J:56996
Biological Process	GO:0006954	inflammatory response	TAS	J:17976
Biological Process	GO:0006954	inflammatory response	TAS	J:4753
Biological Process	GO:0006954	inflammatory response	TAS	J:39746
Biological Process	GO:0048535	lymph node development	IMP	J:47428
Biological Process	GO:0048535	lymph node development	IMP	J:28061
Biological Process	GO:0048535	lymph node development	IMP	J:56996
Biological Process	GO:0048535	lymph node development	IMP	J:43602
Biological Process	GO:0048535	lymph node development	IMP	J:17976
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	TAS	J:17976
Biological Process	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	IGI	J:115034
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IGI	J:115034
Biological Process	GO:0032729	positive regulation of type II interferon production	IGI	J:115034
Biological Process	GO:0032609	type II interferon production	IGI	J:115034