GO Annotations Graph

• Symbol: Lep
• Name: leptin
• ID: MGI:104663

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:262213
Molecular Function	GO:0008083	growth factor activity	IDA	J:38697
Molecular Function	GO:0005179	hormone activity	ISO	J:155856
Molecular Function	GO:0005179	hormone activity	IBA	J:265628
Molecular Function	GO:1990460	leptin receptor binding	ISO	J:164563
Molecular Function	GO:0051428	peptide hormone receptor binding	ISO	J:155856
Molecular Function	GO:0051428	peptide hormone receptor binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:247403
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:196126
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2586548
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2586557
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2586558
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671739
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671740
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671830
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671831
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671832
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671836
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671841
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671843
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671852
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671854
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2671877
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2672295
Cellular Component	GO:0005615	extracellular space	IDA	J:196126
Cellular Component	GO:0005615	extracellular space	IDA	J:47476
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:167584
Cellular Component	GO:0005615	extracellular space	IDA	J:126780
Cellular Component	GO:0005615	extracellular space	IDA	J:81609
Biological Process	GO:1990051	activation of protein kinase C activity	ISO	J:164563
Biological Process	GO:1990051	activation of protein kinase C activity	IBA	J:265628
Biological Process	GO:0060612	adipose tissue development	IGI	J:61493
Biological Process	GO:0008343	adult feeding behavior	IDA	J:47476
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0035904	aorta development	IMP	J:217970
Biological Process	GO:0008206	bile acid metabolic process	IDA	J:78952
Biological Process	GO:0098868	bone growth	IMP	J:60001
Biological Process	GO:0035630	bone mineralization involved in bone maturation	ISO	J:155856
Biological Process	GO:0003300	cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:262213
Biological Process	GO:0044320	cellular response to leptin stimulus	ISO	J:164563
Biological Process	GO:0021954	central nervous system neuron development	IMP	J:59144
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:100492
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:239522
Biological Process	GO:0042755	eating behavior	IGI	J:61883
Biological Process	GO:0051541	elastin metabolic process	IMP	J:217970
Biological Process	GO:0006112	energy reserve metabolic process	ISO	J:155856
Biological Process	GO:0006112	energy reserve metabolic process	IBA	J:265628
Biological Process	GO:0006635	fatty acid beta-oxidation	IGI	J:189021
Biological Process	GO:0009062	fatty acid catabolic process	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	IGI	J:189021
Biological Process	GO:0006006	glucose metabolic process	IMP	J:81609
Biological Process	GO:0006114	glycerol biosynthetic process	ISO	J:155856
Biological Process	GO:0042445	hormone metabolic process	IMP	J:129482
Biological Process	GO:0030073	insulin secretion	IGI	J:129798
Biological Process	GO:0050892	intestinal absorption	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:155856
Biological Process	GO:0033210	leptin-mediated signaling pathway	IDA	J:227387
Biological Process	GO:0033210	leptin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0050901	leukocyte tethering or rolling	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IMP	J:85276
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0032099	negative regulation of appetite	IDA	J:47476
Biological Process	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0010507	negative regulation of autophagy	IMP	J:228103
Biological Process	GO:0061037	negative regulation of cartilage development	ISO	J:155856
Biological Process	GO:0070093	negative regulation of glucagon secretion	IDA	J:168575
Biological Process	GO:0046325	negative regulation of glucose import	ISO	J:164563
Biological Process	GO:2000486	negative regulation of glutamine transport	ISO	J:155856
Biological Process	GO:0010888	negative regulation of lipid storage	ISO	J:155856
Biological Process	GO:0009892	negative regulation of metabolic process	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:168575
Biological Process	GO:0045906	negative regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0001542	ovulation from ovarian follicle	ISO	J:155856
Biological Process	GO:0006909	phagocytosis	ISO	J:155856
Biological Process	GO:0006909	phagocytosis	IDA	J:115105
Biological Process	GO:0001890	placenta development	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249875
Biological Process	GO:0048639	positive regulation of developmental growth	ISO	J:164563
Biological Process	GO:1904651	positive regulation of fat cell apoptotic process	ISO	J:155856
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:115105
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:115105
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:227387
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0043270	positive regulation of monoatomic ion transport	ISO	J:155856
Biological Process	GO:0045639	positive regulation of myeloid cell differentiation	IDA	J:38697
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	IBA	J:265628
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:163162
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IBA	J:265628
Biological Process	GO:0042307	positive regulation of protein import into nucleus	IDA	J:168575
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:227387
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IDA	J:227387
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IDA	J:168575
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	ISO	J:164563
Biological Process	GO:0032008	positive regulation of TOR signaling	IBA	J:265628
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:115105
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0032310	prostaglandin secretion	ISO	J:164563
Biological Process	GO:0045765	regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:155856
Biological Process	GO:0046850	regulation of bone remodeling	IMP	J:60001
Biological Process	GO:0090335	regulation of brown fat cell differentiation	IDA	J:163162
Biological Process	GO:0050790	regulation of catalytic activity	IMP	J:217970
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:227387
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0001936	regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0045598	regulation of fat cell differentiation	IGI	J:189249
Biological Process	GO:0006111	regulation of gluconeogenesis	IMP	J:129482
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:129482
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	IDA	J:78952
Biological Process	GO:0046890	regulation of lipid biosynthetic process	IGI	J:239522
Biological Process	GO:0060587	regulation of lipoprotein lipid oxidation	ISO	J:155856
Biological Process	GO:0019222	regulation of metabolic process	IMP	J:94820
Biological Process	GO:0032814	regulation of natural killer cell activation	ISO	J:164563
Biological Process	GO:0042269	regulation of natural killer cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:0032817	regulation of natural killer cell proliferation	ISO	J:164563
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IDA	J:228116
Biological Process	GO:1900180	regulation of protein localization to nucleus	IMP	J:170032
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:168575
Biological Process	GO:0050810	regulation of steroid biosynthetic process	IMP	J:129482
Biological Process	GO:0002021	response to dietary excess	ISO	J:155856
Biological Process	GO:0002021	response to dietary excess	IMP	J:129798
Biological Process	GO:0002021	response to dietary excess	IGI	J:124244
Biological Process	GO:0032868	response to insulin	IBA	J:265628
Biological Process	GO:0032868	response to insulin	IMP	J:129798
Biological Process	GO:0019953	sexual reproduction	ISO	J:164563
Biological Process	GO:0019953	sexual reproduction	IMP	J:31761
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0030217	T cell differentiation	IMP	J:49623
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA	J:168575
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IBA	J:265628