GO Annotations Graph

• Symbol: Rapgef1
• Name: Rap guanine nucleotide exchange factor (GEF) 1
• ID: MGI:104580

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:115703
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:88364
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:84101
Molecular Function	GO:0005515	protein binding	IPI	J:115703
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9027266
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029146
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029147
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029152
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9029162
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9030346
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9030353
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0030670	phagocytic vesicle membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:220382
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:220382
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:220382
Biological Process	GO:0001568	blood vessel development	IMP	J:80219
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:119299
Biological Process	GO:0098609	cell-cell adhesion	IMP	J:80219
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IGI	J:119299
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:119299
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IGI	J:119299
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IMP	J:119299
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	IGI	J:119299
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IMP	J:119299
Biological Process	GO:0038180	nerve growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0061351	neural precursor cell proliferation	IMP	J:119299
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:80219
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:119299
Biological Process	GO:0032486	Rap protein signal transduction	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0007265	Ras protein signal transduction	IMP	J:119299
Biological Process	GO:1901888	regulation of cell junction assembly	ISO	J:164563
Biological Process	GO:0046328	regulation of JNK cascade	ISO	J:155856