GO Annotations Graph

• Symbol: Umod
• Name: uromodulin
• ID: MGI:102674

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0019864	IgG binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:289677
Molecular Function	GO:0005515	protein binding	IPI	J:289677
Molecular Function	GO:0005515	protein binding	IPI	J:289677
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IBA	J:265628
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:286774
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:171500
Cellular Component	GO:0016324	apical plasma membrane	ISS	J:132048
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:171500
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0005929	cilium	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:286730
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:196497
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:196497
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:196497
Cellular Component	GO:0000922	spindle pole	ISO	J:164563
Biological Process	GO:0140367	antibacterial innate immune response	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IMP	J:252420
Biological Process	GO:0097190	apoptotic signaling pathway	IMP	J:252597
Biological Process	GO:0006914	autophagy	IMP	J:252597
Biological Process	GO:0055074	calcium ion homeostasis	IMP	J:163552
Biological Process	GO:0055074	calcium ion homeostasis	IMP	J:286774
Biological Process	GO:0033554	cellular response to stress	IMP	J:253623
Biological Process	GO:0034620	cellular response to unfolded protein	IMP	J:289677
Biological Process	GO:0061077	chaperone-mediated protein folding	IMP	J:289677
Biological Process	GO:0048878	chemical homeostasis	IMP	J:121470
Biological Process	GO:0032602	chemokine production	IMP	J:253623
Biological Process	GO:0055064	chloride ion homeostasis	IMP	J:281266
Biological Process	GO:0046720	citric acid secretion	IMP	J:163552
Biological Process	GO:0072044	collecting duct development	IMP	J:127526
Biological Process	GO:0097709	connective tissue replacement	IMP	J:253623
Biological Process	GO:0097709	connective tissue replacement	IMP	J:252420
Biological Process	GO:0050829	defense response to Gram-negative bacterium	ISO	J:164563
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:97228
Biological Process	GO:0050829	defense response to Gram-negative bacterium	IMP	J:95431
Biological Process	GO:0007029	endoplasmic reticulum organization	IMP	J:289677
Biological Process	GO:0010467	gene expression	IMP	J:96653
Biological Process	GO:0010467	gene expression	IMP	J:196497
Biological Process	GO:0010467	gene expression	IMP	J:289677
Biological Process	GO:0010467	gene expression	IMP	J:253623
Biological Process	GO:0010467	gene expression	IMP	J:252420
Biological Process	GO:0010467	gene expression	IMP	J:281266
Biological Process	GO:0010467	gene expression	IMP	J:286774
Biological Process	GO:0003094	glomerular filtration	IMP	J:96653
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IMP	J:253623
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:127526
Biological Process	GO:0030644	intracellular chloride ion homeostasis	IMP	J:127526
Biological Process	GO:0030644	intracellular chloride ion homeostasis	IDA	J:176621
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	IMP	J:127526
Biological Process	GO:0006883	intracellular sodium ion homeostasis	IMP	J:127526
Biological Process	GO:0072051	juxtaglomerular apparatus development	IMP	J:96653
Biological Process	GO:0001822	kidney development	IMP	J:252597
Biological Process	GO:0001822	kidney development	IMP	J:252420
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IMP	J:253623
Biological Process	GO:0072070	loop of Henle development	IMP	J:96653
Biological Process	GO:0072218	metanephric ascending thin limb development	IEP	J:138858
Biological Process	GO:0072221	metanephric distal convoluted tubule development	IEP	J:138858
Biological Process	GO:0072233	metanephric thick ascending limb development	IEP	J:138858
Biological Process	GO:0060073	micturition	IMP	J:286752
Biological Process	GO:0050801	monoatomic ion homeostasis	IMP	J:173004
Biological Process	GO:0033555	multicellular organismal response to stress	IMP	J:286752
Biological Process	GO:0048871	multicellular organismal-level homeostasis	IMP	J:252420
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	IMP	J:281266
Biological Process	GO:1990266	neutrophil migration	ISO	J:164563
Biological Process	GO:1990266	neutrophil migration	IBA	J:265628
Biological Process	GO:0002251	organ or tissue specific immune response	IMP	J:252597
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IMP	J:286774
Biological Process	GO:0055062	phosphate ion homeostasis	IMP	J:163552
Biological Process	GO:0055075	potassium ion homeostasis	IMP	J:281266
Biological Process	GO:0072665	protein localization to vacuole	IMP	J:286753
Biological Process	GO:0006468	protein phosphorylation	IMP	J:176621
Biological Process	GO:0006468	protein phosphorylation	IDA	J:176621
Biological Process	GO:0044861	protein transport into plasma membrane raft	IMP	J:281266
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:281266
Biological Process	GO:0051223	regulation of protein transport	IMP	J:252420
Biological Process	GO:0051223	regulation of protein transport	IMP	J:281266
Biological Process	GO:0035809	regulation of urine volume	IMP	J:252420
Biological Process	GO:0035809	regulation of urine volume	IMP	J:281266
Biological Process	GO:0070294	renal sodium ion absorption	IMP	J:176621
Biological Process	GO:0070294	renal sodium ion absorption	IDA	J:176621
Biological Process	GO:0097744	renal urate salt excretion	IMP	J:281266
Biological Process	GO:0003091	renal water homeostasis	IMP	J:96653
Biological Process	GO:0036270	response to diuretic	IMP	J:281266
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:252597
Biological Process	GO:0032496	response to lipopolysaccharide	IDA	J:286727
Biological Process	GO:0006986	response to unfolded protein	IMP	J:252420
Biological Process	GO:0009414	response to water deprivation	IMP	J:96653
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:286774
Biological Process	GO:0008380	RNA splicing	IMP	J:289677
Biological Process	GO:0055078	sodium ion homeostasis	IMP	J:281266
Biological Process	GO:0055078	sodium ion homeostasis	IMP	J:286774
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IMP	J:252597
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IMP	J:289677
Biological Process	GO:0015747	urate transport	IMP	J:281266
Biological Process	GO:0071918	urea transmembrane transport	IMP	J:121470