Isl1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Isl1
ISL1 transcription factor, LIM/homeodomain
MGI:101791

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:134978
Molecular Function	GO:0003682	chromatin binding	IDA	J:134978
Molecular Function	GO:0003682	chromatin binding	IDA	J:134978
Molecular Function	GO:0003682	chromatin binding	IDA	J:158135
Molecular Function	GO:0003682	chromatin binding	IDA	J:174563
Molecular Function	GO:0003682	chromatin binding	IDA	J:134978
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IDA	J:158135
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:99220
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:239195
Molecular Function	GO:0005515	protein binding	IPI	J:200395
Molecular Function	GO:0005515	protein binding	IPI	J:239195
Molecular Function	GO:0005515	protein binding	IPI	J:239195
Molecular Function	GO:0005515	protein binding	IPI	J:160776
Molecular Function	GO:0005515	protein binding	IPI	J:152175
Molecular Function	GO:0005515	protein binding	IPI	J:212665
Molecular Function	GO:0005515	protein binding	IPI	J:41049
Molecular Function	GO:0005515	protein binding	IPI	J:99220
Molecular Function	GO:0005515	protein binding	IPI	J:41049
Molecular Function	GO:0005515	protein binding	IPI	J:41049
Molecular Function	GO:0005515	protein binding	IPI	J:56497
Molecular Function	GO:0005515	protein binding	IPI	J:99220
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:239195
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:328860
Cellular Component	GO:0000785	chromatin	IDA	J:328860
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9010548
Cellular Component	GO:0005634	nucleus	IDA	J:239224
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:198828
Cellular Component	GO:0005634	nucleus	IDA	J:57955
Cellular Component	GO:0005634	nucleus	IDA	J:57955
Cellular Component	GO:0005634	nucleus	IDA	J:127471
Cellular Component	GO:0005634	nucleus	IDA	J:213584
Cellular Component	GO:0005634	nucleus	IDA	J:218609
Cellular Component	GO:0005634	nucleus	IDA	J:84600
Cellular Component	GO:0005634	nucleus	IDA	J:134978
Cellular Component	GO:0005634	nucleus	IDA	J:99220
Cellular Component	GO:0005634	nucleus	IDA	J:87397
Cellular Component	GO:0005634	nucleus	IDA	J:152175
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Biological Process	GO:0060413	atrial septum morphogenesis	IGI	J:143832
Biological Process	GO:0007409	axonogenesis	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:158135
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:158135
Biological Process	GO:0060913	cardiac cell fate determination	ISO	J:164563
Biological Process	GO:0060913	cardiac cell fate determination	IMP	J:158135
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	IMP	J:158135
Biological Process	GO:0003215	cardiac right ventricle morphogenesis	IGI	J:143832
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IDA	J:99220
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:143832
Biological Process	GO:0007507	heart development	IMP	J:95093
Biological Process	GO:0007507	heart development	IMP	J:95093
Biological Process	GO:0007507	heart development	IMP	J:95093
Biological Process	GO:0003007	heart morphogenesis	IGI	J:110602
Biological Process	GO:0060384	innervation	IMP	J:141110
Biological Process	GO:0048762	mesenchymal cell differentiation	IMP	J:37641
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:158135
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:187645
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:141110
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:89755
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:141110
Biological Process	GO:0001755	neural crest cell migration	IGI	J:110602
Biological Process	GO:0030182	neuron differentiation	IGI	J:134987
Biological Process	GO:0030182	neuron differentiation	IGI	J:89755
Biological Process	GO:0030182	neuron differentiation	IMP	J:133494
Biological Process	GO:0030182	neuron differentiation	IMP	J:31131
Biological Process	GO:0030182	neuron differentiation	IMP	J:133494
Biological Process	GO:0048663	neuron fate commitment	IGI	J:89755
Biological Process	GO:0048665	neuron fate specification	IMP	J:141110
Biological Process	GO:0048665	neuron fate specification	IBA	J:265628
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:143832
Biological Process	GO:0003148	outflow tract septum morphogenesis	IGI	J:143832
Biological Process	GO:0031016	pancreas development	IMP	J:37641
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	IMP	J:141110
Biological Process	GO:0048935	peripheral nervous system neuron development	IGI	J:174563
Biological Process	GO:0060037	pharyngeal system development	IGI	J:143832
Biological Process	GO:0021983	pituitary gland development	IMP	J:50517
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:187645
Biological Process	GO:0045597	positive regulation of cell differentiation	IMP	J:220735
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:99220
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:99220
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:155856
Biological Process	GO:0071657	positive regulation of granulocyte colony-stimulating factor production	IDA	J:187645
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IDA	J:187645
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production	IDA	J:187645
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:187645
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:187645
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:187645
Biological Process	GO:1901258	positive regulation of macrophage colony-stimulating factor production	IDA	J:187645
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:141110
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:239224
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:239195
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:134978
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:212665
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:158135
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:187645
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:187645
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:99220
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IDA	J:187645
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IMP	J:152175
Biological Process	GO:0010468	regulation of gene expression	IMP	J:152175
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:224516
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation	IMP	J:158135
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IMP	J:134978
Biological Process	GO:0003139	secondary heart field specification	ISO	J:164563
Biological Process	GO:0048880	sensory system development	IMP	J:141110
Biological Process	GO:0060931	sinoatrial node cell development	IMP	J:224516
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	IGI	J:152175
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IMP	J:31131
Biological Process	GO:0048863	stem cell differentiation	IMP	J:37641
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:212665
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:212665
Biological Process	GO:0021559	trigeminal nerve development	IMP	J:141110
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IGI	J:143832
Biological Process	GO:0021524	visceral motor neuron differentiation	IGI	J:89755

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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