Ccn3 MGI Mouse Gene Detail - MGI:109185 - cellular communication network factor 3

Symbol

Ccn3
Name

cellular communication network factor 3
Synonyms

C130088N23Rik, CCN3, Nov

Feature Type

protein coding gene
IDs

MGI:109185
NCBI Gene: 18133
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:54609306-54617158 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 21.49 cM
Mapping Data

3 experiments

SNPs within 2kb

100 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109185	protein coding gene	Chr15:54609098-54617435 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021849	protein coding gene	Chr15:53795938-53805573 (+)
A/J	MGP_AJ_G0021809	protein coding gene	Chr15:51660978-51670208 (+)
AKR/J	MGP_AKRJ_G0021790	protein coding gene	Chr15:53126674-53134809 (+)
BALB/cJ	MGP_BALBcJ_G0021816	protein coding gene	Chr15:51893702-51902306 (+)
C3H/HeJ	MGP_C3HHeJ_G0021590	protein coding gene	Chr15:53212773-53220958 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022255	protein coding gene	Chr15:55884515-55892764 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019792	protein coding gene	Chr15:48913938-48922008 (+)
CAST/EiJ	MGP_CASTEiJ_G0021107	protein coding gene	Chr15:53778710-53787949 (+)
CBA/J	MGP_CBAJ_G0021559	protein coding gene	Chr15:57904485-57912712 (+)
DBA/2J	MGP_DBA2J_G0021683	protein coding gene	Chr15:51562213-51571449 (+)
FVB/NJ	MGP_FVBNJ_G0021661	protein coding gene	Chr15:50687883-50696261 (+)
LP/J	MGP_LPJ_G0021753	protein coding gene	Chr15:53596094-53604151 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021685	protein coding gene	Chr15:62964054-62974376 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022278	protein coding gene	Chr15:53468911-53477076 (+)
PWK/PhJ	MGP_PWKPhJ_G0020852	protein coding gene	Chr15:51621424-51630391 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020689	protein coding gene	Chr15:53193083-53202912 (+)
WSB/EiJ	MGP_WSBEiJ_G0021162	protein coding gene	Chr15:53460344-53469562 (+)

Human Ortholog

CCN3, cellular communication network factor 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCN3, cellular communication network factor 3
Synonyms

IBP-9, IGFBP9, IGFBP-9, NOV, NOVh
Links

HGNC:7885

NCBI Gene ID: 4856

neXtProt AC: NX_P48745

UniProt: P48745
Chr Location

8q24.12; chr8:119416446-119424434 (+) GRCh38

MGI Vertebrate Homology

Ccn3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CCN3
Protein SuperFamily

IGFBP_rP_CNN
Gene Tree

Ccn3

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References

1 with disease annotations

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Phenotype Summary

53 phenotypes from 4 alleles in 4 genetic backgrounds
5 images
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

3
Endonuclease-mediated

3
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Ccn3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Heterozygotes and homozygotes for a null mutation exhibit abnormal skeletal and cardiac development, muscle atrophy and cataracts. Mice homozygous for another knock-out allele exhibit minor bone structure and physiology defects.

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All GO Annotations

69
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

891
Tissues

151
cDNA Data

31
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCN3

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS27471.1

Ensembl

ENSMUSG00000037362 (Evidence)
NCBI Gene

18133

			Length	Strain/Species	Flank
genomic	18133	NCBI Gene Model \| MGI Sequence Detail	7853	C57BL/6J	± kb
transcript	NM_010930	RefSeq \| MGI Sequence Detail	2384	ZRU/MplStud
polypeptide	Q64299	UniProt \| EBI \| MGI Sequence Detail	354	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011338 protein NOV

(term hierarchy)
InterPro Domains

IPR043973 CCN, TSP1 domain

IPR006207 Cystine knot, C-terminal

IPR006208 Glycoprotein hormone subunit beta

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR012395 IGFBP-related, CNN

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR001007 VWFC domain

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All nucleic 41

Genomic 2

cDNA 32

Primer pair 6

Other 1

Microarray probesets 4

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MGD-MRK-38229, MGI:2443171

Summaries

All 83

Developmental Gene Expression 25

Diseases 1

Gene Ontology 12

Phenotypes 25
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:344523 Tu P, et al., Myeloid CCN3 protects against aortic valve calcification. Cell Commun Signal. 2023 Jan 20;21(1):14

TSS for Ccn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131281	Chr15:54609011-54609028 (+)	-286 bp
Tssr131282	Chr15:54609266-54609277 (+)	-34 bp
Tssr131283	Chr15:54609298-54609312 (+)	-1 bp
Tssr131284	Chr15:54616378-54616413 (+)	7,090 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23