Fbp2 MGI Mouse Gene Detail - MGI:95491 - fructose bisphosphatase 2

Symbol

Fbp2
Name

fructose bisphosphatase 2
Synonyms

Fbp-1, FBPase muscle

Feature Type

protein coding gene
IDs

MGI:95491
NCBI Gene: 14120
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:62984698-63006214 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 32.74 cM
Mapping Data

2 experiments

SNPs within 2kb

339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95491	protein coding gene	Chr13:62984691-63006236 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020666	protein coding gene	Chr13:62759951-62787201 (-)
A/J	MGP_AJ_G0020620	protein coding gene	Chr13:60510403-60532289 (-)
AKR/J	MGP_AKRJ_G0020597	protein coding gene	Chr13:62528429-62551249 (-)
BALB/cJ	MGP_BALBcJ_G0020618	protein coding gene	Chr13:60928655-60949947 (-)
C3H/HeJ	MGP_C3HHeJ_G0020413	protein coding gene	Chr13:62066283-62087897 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021052	protein coding gene	Chr13:64828761-64850231 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018630	protein coding gene	Chr13:58190128-58211608 (-)
CAST/EiJ	MGP_CASTEiJ_G0019929	protein coding gene	Chr13:62053379-62075990 (-)
CBA/J	MGP_CBAJ_G0020373	protein coding gene	Chr13:67316563-67342670 (-)
DBA/2J	MGP_DBA2J_G0020498	protein coding gene	Chr13:60350185-60373642 (-)
FVB/NJ	MGP_FVBNJ_G0020477	protein coding gene	Chr13:59461737-59486270 (-)
LP/J	MGP_LPJ_G0020572	protein coding gene	Chr13:63063373-63085460 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020506	protein coding gene	Chr13:66325706-66349993 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021096	protein coding gene	Chr13:61826909-61849166 (-)
PWK/PhJ	MGP_PWKPhJ_G0019683	protein coding gene	Chr13:59899031-59921183 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019510	protein coding gene	Chr13:59984738-60008935 (-)
WSB/EiJ	MGP_WSBEiJ_G0019990	protein coding gene	Chr13:62333439-62357267 (-)

Human Ortholog

FBP2, fructose-bisphosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBP2, fructose-bisphosphatase 2
Synonyms

CORLK
Links

HGNC:3607

NCBI Gene ID: 8789

neXtProt AC: NX_O00757

UniProt: O00757
Chr Location

9q22.32; chr9:94558720-94593824 (-) GRCh38

MGI Vertebrate Homology

Fbp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBP2
Protein SuperFamily

FBPtase_SBPase
Gene Tree

Fbp2

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Fbp2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

This locus controls electrophoretic variation of fructose bisphosphatase isozymes in muscle. Isozymes of kidney, liver and testis are not affected. P, SEA, SWR and Peru-Coppock have a slow migrating band; SM, C3H/He, C57BL/Go, CE and DBA/2 have a fast migrating band. Heterozygotes are intermediate.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

195
cDNA Data

34
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbp2

ZFIN fbp2

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All Sequences

51
RefSeq

2
UniProt

3
CCDS

CCDS36698.1

Ensembl

ENSMUSG00000021456 (Evidence)
NCBI Gene

14120

			Length	Strain/Species	Flank
genomic	14120	NCBI Gene Model \| MGI Sequence Detail	21517	C57BL/6J	± kb
transcript	NM_007994	RefSeq \| MGI Sequence Detail	1325	C57BL/6
polypeptide	P70695	UniProt \| EBI \| MGI Sequence Detail	339	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007366 fructose-1,6-bisphosphatase isozyme 2

(term hierarchy)
EC

3.1.3.11
InterPro Domains

IPR028343 Fructose-1,6-bisphosphatase

IPR020548 Fructose-1,6-bisphosphatase, active site

IPR000146 Fructose-1,6-bisphosphatase class 1

IPR044015 Fructose-1-6-bisphosphatase class 1, C-terminal

IPR033391 Fructose-1-6-bisphosphatase class I, N-terminal

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All nucleic 36

Genomic 1

cDNA 34

Primer pair 1

Microarray probesets 3

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MGD-MRK-9719, MGD-MRK-9721

Summaries

All 57

Developmental Gene Expression 11

Gene Ontology 7

Phenotypes 10
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:340032 Paredes A, et al., gamma-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature. 2023 Jun;618(7964):365-373

TSS for Fbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122961	Chr13:63006516-63006537 (-)	-313 bp
Tssr122960	Chr13:63006229-63006239 (-)	-20 bp
Tssr122959	Chr13:63006178-63006225 (-)	12 bp
Tssr122958	Chr13:63006160-63006173 (-)	47 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23