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Cxcl13 Gene Detail
Summary
  • Symbol
    Cxcl13
  • Name
    C-X-C motif chemokine ligand 13
  • Synonyms
    4631412M08Rik, ANGIE2, BCA-1, BLC, Scyb13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888499
    NCBI Gene: 55985
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:96104810-96108927 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.29 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888499
protein coding gene Chr5:96104785-96108927 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029762
protein coding gene Chr5:97175084-97179202 (+)
A/J MGP_AJ_G0029728
protein coding gene Chr5:93616017-93620134 (+)
AKR/J MGP_AKRJ_G0029674
protein coding gene Chr5:96744476-96748593 (+)
BALB/cJ MGP_BALBcJ_G0029738
protein coding gene Chr5:94617898-94622015 (+)
C3H/HeJ MGP_C3HHeJ_G0029461
protein coding gene Chr5:97090077-97094194 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030193
protein coding gene Chr5:101353349-101357466 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027428
protein coding gene Chr5:89043721-89049730 (+)
CAST/EiJ MGP_CASTEiJ_G0028871
protein coding gene Chr5:95660556-95664675 (+)
CBA/J MGP_CBAJ_G0029431
protein coding gene Chr5:104848419-104852536 (+)
DBA/2J MGP_DBA2J_G0029575
protein coding gene Chr5:93829318-93833435 (+)
FVB/NJ MGP_FVBNJ_G0029534
protein coding gene Chr5:92666183-92670300 (+)
LP/J MGP_LPJ_G0029663
protein coding gene Chr5:97846248-97850366 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029563
protein coding gene Chr5:109876713-109880830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030226
protein coding gene Chr5:96173725-96177842 (+)
PWK/PhJ MGP_PWKPhJ_G0028590
protein coding gene Chr5:92246437-92250554 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028425
protein coding gene Chr5:93848265-93852400 (+)
WSB/EiJ MGP_WSBEiJ_G0028950
protein coding gene Chr5:96497571-96501689 (+)



Homology
more
  • Human Ortholog
    CXCL13, C-X-C motif chemokine ligand 13
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL13, C-X-C motif chemokine ligand 13
  • Synonyms
    ANGIE, ANGIE2, BCA1, BCA-1, BLC, BLR1L, SCYB13
  • Links
    NCBI Gene ID: 10563
    neXtProt AC: NX_O43927
    UniProt: O43927

  • Chr Location
    4q21.1; chr4:77511753-77611834 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
B lymphocyte trafficking is impaired in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023078 Ensembl Gene Model | MGI Sequence Detail 4118 C57BL/6J ±  kb
    transcript ENSMUST00000023840 Ensembl | MGI Sequence Detail 1150 Not Applicable  
    polypeptide ENSMUSP00000023840 Ensembl | MGI Sequence Detail 109 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918033
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 22
      Gene Ontology 9
      Phenotypes 52
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:337474 Cobo I, et al., NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory