Jak3
Gene Detail

Symbol Name ID

Jak3 Janus kinase 3 MGI:99928

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:71676296-71690575 bp, + strand From VEGA annotation of GRCm38   14280 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:181  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak3

Human homologs

Human Homolog		JAK3, Janus kinase 3
NCBI Gene ID		3718
neXtProt AC		NX_P52333
Human Synonyms		JAK-3, JAK3_HUMAN, JAKL, LJAK, L-JAK
Human Chr (Location)		19p13.1; chr19:17935591-17958841 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human JAK3

Alleles and phenotypes

All alleles(23) : Targeted(5) Gene trapped(14) Spontaneous(1) Chemically induced(3)
 

Mice homozygous for a knock-out allele exhibit impaired B cell development, small thymi and T cell proliferate. Point mutation homozygotes develop autoimmune inflammatory bowel disease, decreased susceptibility to malaria infection and/or increased susceptibility to bacterial infection.

 
Human Diseases Modeled Using Mouse Jak3 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	B cell differentiation, cytokine-mediated signaling pathway, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021111 (Evidence)
Ensembl Gene Model	ENSMUSG00000031805 (Evidence)
Entrez Gene	16453 (Evidence)
DFCI	TC1577507
DoTS	DT.101207308, DT.101286043, DT.101363930, DT.536101, DT.91289212, DT.99845221
EC	2.7.10.2
Consensus CDS Project	CCDS22403.1
International Mouse Knockout Project Status	Jak3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021111	VEGA Gene Model | MGI Sequence Detail	14280	C57BL/6J
transcript	OTTMUST00000049963	VEGA | MGI Sequence Detail	4009	Not Applicable
polypeptide	OTTMUSP00000023248	VEGA | MGI Sequence Detail	1100	Not Applicable

All sequences(45) RefSeq(4) UniProt(1)

Polymorphisms

PCR(1) : SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR000299	FERM domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR020775	Tyrosine-protein kinase, non-receptor Jak3
InterPro	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology	PR:000009198	tyrosine-protein kinase JAK3

References

(Earliest) J:19201 Witthuhn BA, et al., Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 1994 Jul 14;370(6485):153-7
(Latest) J:194747 Bell BD, et al., The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013 Apr;14(4):364-71
All references(111)

Other accession IDs

MGD-MRK-16730, MGI:3584392, MGI:3584403