Nr3c2
Gene Detail

Symbol Name ID

Nr3c2 nuclear receptor subfamily 3, group C, member 2 MGI:99459

Synonyms

aldosterone receptor, mineralocorticoid receptor, Mlr, MR

Feature Type

protein coding gene

Genetic Map

Chromosome 8

36.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr8:76899442-77245012 bp, + strand From VEGA annotation of GRCm38   345571 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:121495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: mineralocorticoid receptor
Gene Tree: Nr3c2

Human homologs

Human Homolog		NR3C2, nuclear receptor subfamily 3, group C, member 2
NCBI Gene ID		4306
neXtProt AC		NX_P08235
Human Synonyms		MCR, MLR, MR, NR3C2VIT
Human Chr (Location)		4q31.1; chr4:148999915-149363672 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NR3C2

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Mice homozygous for a targeted null mutation exhibit weight loss and symptoms of pseudohypoaldosteronism, and eventually die at around day 10 after birth from renal salt wasting and dehydration.

 
Human Diseases Modeled Using Mouse Nr3c2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cellular sodium ion homeostasis, excretion, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	DNA binding, double-stranded DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (77)    Tissues (54)    Images (9)
Theiler Stages: 17, 21, 23, 26, 28

Assay Type	Results
RNA in situ	75
RT-PCR	2

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(36) cDNA(8) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000022950 (Evidence)
Ensembl Gene Model	ENSMUSG00000031618 (Evidence)
Entrez Gene	110784 (Evidence)
DFCI	TC1603749, TC1638096, TC1728714
DoTS	DT.102555488, DT.55143994, DT.87026746
NIA Mouse Gene Index	U042914
Consensus CDS Project	CCDS40393.1
International Mouse Knockout Project Status	Nr3c2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022950	VEGA Gene Model | MGI Sequence Detail	345571	C57BL/6J
transcript	OTTMUST00000055203	VEGA | MGI Sequence Detail	2955	Not Applicable
polypeptide	OTTMUSP00000026407	VEGA | MGI Sequence Detail	984	Not Applicable

All sequences(56) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(2) : SNPs(1141 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011407	mineralocorticoid receptor

References

(Earliest) J:20783 Peters J, et al., New gene symbols. Mouse Genome. 1994;92(3):360-66
(Latest) J:193438 McCurley A, et al., Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Sep;18(9):1429-33
All references(79)

Other accession IDs

MGD-MRK-16228