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Nr3c2
Gene Detail
 Symbol
Name
ID
Nr3c2
nuclear receptor subfamily 3, group C, member 2
MGI:99459
Synonyms aldosterone receptor, mineralocorticoid receptor, Mlr, MR
Feature Type protein coding gene
Genetic Map
Chromosome 8
36.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr8:76899442-77245012 bp, + strand
From VEGA annotation of GRCm38

  345571 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121495  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: mineralocorticoid receptor
Gene Tree: Nr3c2

Human
homologs
Human Homolog NR3C2, nuclear receptor subfamily 3, group C, member 2
NCBI Gene ID 4306
neXtProt AC  NX_P08235
Human Synonyms  MCR, MLR, MR, NR3C2VIT
Human Chr (Location)  4q31.1; chr4:148078764-148444698 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NR3C2
Alleles
and
phenotypes
All alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit weight loss and symptoms of pseudohypoaldosteronism, and eventually die at around day 10 after birth from renal salt wasting and dehydration.
 
Human Diseases Modeled Using Mouse Nr3c2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular sodium ion homeostasis, excretion, ...
Component cytoplasm, endoplasmic reticulum, ...
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (77)    Tissues (54)    Images (9)
Theiler Stages: 17, 21, 23, 26, 27, 28
Assay TypeResults
RNA in situ 75
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) Genomic(36) cDNA(8) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000022950 (Evidence)
Ensembl Gene ModelENSMUSG00000031618 (Evidence)
Entrez Gene110784 (Evidence)
DFCITC1603749, TC1638096, TC1728714
DoTSDT.102555488, DT.55143994, DT.87026746
NIA Mouse Gene IndexU042914
Consensus CDS ProjectCCDS40393.1
International Mouse Knockout Project StatusNr3c2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022950 VEGA Gene Model | MGI Sequence Detail 345571 C57BL/6J ±  kb
transcript OTTMUST00000055203 VEGA | MGI Sequence Detail 2955 Not Applicable 
polypeptide OTTMUSP00000026407 VEGA | MGI Sequence Detail 984 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(8)
Polymorphisms RFLP(2) : SNPs within 2kb(1462 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011407 mineralocorticoid receptor
References (Earliest) J:20783 Peters J, et al., New gene symbols. Mouse Genome. 1994;92(3):360-66
(Latest) J:202992 Zhang X, et al., Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase alphaENaC transcription. Am J Physiol Renal Physiol. 2013 Nov;305(10):F1436-44
All references(87)
Other
accession IDs
MGD-MRK-16228

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory