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Irs1
Gene Detail
 Symbol
Name
ID
Irs1
insulin receptor substrate 1
MGI:99454
Synonyms G972R, IRS-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
42.00 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:82233101-82291416 bp, - strand
From VEGA annotation of GRCm38

  58316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4049  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: insulin receptor substrate
Gene Tree: Irs1

Human
homologs
Human Homolog IRS1, insulin receptor substrate 1
NCBI Gene ID 3667
neXtProt AC  NX_P35568
Human Synonyms  HIRS-1
Human Chr (Location)  2q36; chr2:226731317-226799829 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IRS1
Alleles
and
phenotypes
All alleles(8) : Targeted(6) Spontaneous(2)
 
Homozygotes for targeted null mutations exhibit 50 percent reductions in body weights at birth and at 4 months of age, impaired glucose tolerance, and mild insulin and IGF-1 resistance.
 
Human Diseases Modeled Using Mouse Irs1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process cellular response to insulin stimulus, insulin-like growth factor receptor signaling pathway, ...
Component caveola, cytoplasm, ...
Function insulin-like growth factor receptor binding, insulin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (60)    Tissues (51)    Images (4)
Theiler Stages: 4, 10, 18, 20, 23, 25, 28
Assay TypeResults
Northern blot 6
RT-PCR 54
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(7) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016464 (Evidence)
Ensembl Gene ModelENSMUSG00000055980 (Evidence)
Entrez Gene16367 (Evidence)
DFCITC1583609, TC1597364, TC1717587
DoTSDT.101736484, DT.91288547, DT.91442113
PDB1AYB
Consensus CDS ProjectCCDS15096.1
International Mouse Knockout Project StatusIrs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016464 VEGA Gene Model | MGI Sequence Detail 58316 C57BL/6J ±  kb
transcript OTTMUST00000039671 VEGA | MGI Sequence Detail 9144 Not Applicable 
polypeptide OTTMUSP00000017705 VEGA | MGI Sequence Detail 1231 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(404 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000009107 insulin receptor substrate 1
References (Earliest) J:4645 Keller SR, et al., The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning. Biochim Biophys Acta. 1993 Mar 20;1172(3):323-6
(Latest) J:205902 Tao R, et al., Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. PLoS One. 2013;8(8):e71997
All references(160)
Other
accession IDs
MGD-MRK-16223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory