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Irs1
Gene Detail
Symbol

Name
ID
Irs1
insulin receptor substrate 1
MGI:99454
Synonyms
G972R, IRS-1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
42.00 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:82233101-82291416 bp, - strand
From VEGA annotation of GRCm38

  58316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4049  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRS1
Protein SuperFamily: insulin receptor substrate
Gene Tree: Irs1

Human
homologs
IRS1, insulin receptor substrate 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3667
neXtProt AC: NX_P35568

Human Synonyms: HIRS-1

Human Chr (Location): 2q36; chr2:226731317-226798790 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IRS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Spontaneous(2) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit 50 percent reductions in body weights at birth and at 4 months of age, impaired glucose tolerance, and mild insulin and IGF-1 resistance.
 
Human Diseases Modeled in Mice Using Irs1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Irs1 interacts with 398 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (58)    Tissues (50)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 6
RT-PCR 52
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100495320    NEW 
Molecular
reagents
All nucleic(23) Genomic(7) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016464 (Evidence)
Ensembl Gene Model ENSMUSG00000055980 (Evidence)
Entrez Gene 16367 (Evidence)
DFCI TC1583609, TC1597364, TC1717587
DoTS DT.101736484, DT.91288547, DT.91442113
PDB 1AYB
Consensus CDS Project CCDS15096.1
International Mouse Phenotyping Consortium Status Irs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016464 VEGA Gene Model | MGI Sequence Detail 58316 C57BL/6J ±  kb
transcript OTTMUST00000039671 VEGA | MGI Sequence Detail 9144 Not Applicable 
polypeptide OTTMUSP00000017705 VEGA | MGI Sequence Detail 1231 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(404 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000009107 insulin receptor substrate 1
References
(Earliest) J:4645 Keller SR, et al., The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning. Biochim Biophys Acta. 1993 Mar 20;1172(3):323-6
(Latest) J:215385 Page MM, et al., Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell. 2014 Oct;13(5):962-4
All references(166)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory