Zfp36
Gene Detail

Symbol Name ID

Zfp36 zinc finger protein 36 MGI:99180

Synonyms

Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36

Feature Type

protein coding gene

Genetic Map

Chromosome 7

16.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr7:28376784-28379255 bp, - strand From VEGA annotation of GRCm38   2472 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Zfp36

Human homologs

Human Homolog		ZFP36, ZFP36 ring finger protein
NCBI Gene ID		7538
neXtProt AC		NX_P26651
Human Synonyms		G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
Human Chr (Location)		19q13.1; chr19:39406847-39409412 (+)  GRCh38

Alleles and phenotypes

All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes are normal at birth but soon develop myeloid hyperplasia, cachexia, patchy alopecia, dermatitis, arthritis, loss of adiposity, conjunctivitis, glomerular mesangial thickening and autoimmunity, with variable severity. All aspects of the syndrome are normalized by TNF antibody treatment.

 

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	3'-UTR-mediated mRNA stabilization, intracellular signal transduction, ...
Component	cytoplasm, cytoplasmic stress granule, ...
Function	14-3-3 protein binding, AU-rich element binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (206)    Tissues (97)    Images (8)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	44
Northern blot	9
RT-PCR	153

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(78) Genomic(9) cDNA(60) Primer pair(5) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021115 (Evidence)
Ensembl Gene Model	ENSMUSG00000044786 (Evidence)
Entrez Gene	22695 (Evidence)
UniGene	389856
DFCI	TC1574344, TC1749760
DoTS	DT.101342640, DT.101384237, DT.99867541
NIA Mouse Gene Index	U028323
PDB	1M9O
Consensus CDS Project	CCDS21041.1
International Mouse Knockout Project Status	Zfp36

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021115	VEGA Gene Model | MGI Sequence Detail	2472	C57BL/6J
transcript	OTTMUST00000049971	VEGA | MGI Sequence Detail	1792	Not Applicable
polypeptide	OTTMUSP00000023255	VEGA | MGI Sequence Detail	319	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(5 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
Protein Ontology	PR:000017639	tristetraprolin

References

(Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:207684 Blanco FF, et al., Transforming growth factor beta regulates P-body formation through induction of the mRNA decay factor tristetraprolin. Mol Cell Biol. 2014 Jan;34(2):180-95
All references(101)

Other accession IDs

MGD-MRK-15295, MGD-MRK-15877, MGD-MRK-15932