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Zfp36 Gene Detail
Summary
  • Symbol
    Zfp36
  • Name
    zinc finger protein 36
  • Synonyms
    Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36
  • Feature Type
    protein coding gene
  • IDs
    MGI:99180
    NCBI Gene: 22695
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28076208-28078680 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.72 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99180
 protein coding gene Chr7:28076208-28079678 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031942
 protein coding gene Chr7:27159523-27161996 (-)
A/J MGP_AJ_G0031921
 protein coding gene Chr7:26500498-26502968 (-)
AKR/J MGP_AKRJ_G0031852
 protein coding gene Chr7:27176370-27178841 (-)
BALB/cJ MGP_BALBcJ_G0031927
 protein coding gene Chr7:26658880-26661350 (-)
C3H/HeJ MGP_C3HHeJ_G0031649
 protein coding gene Chr7:27555099-27557568 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032392
 protein coding gene Chr7:28031199-28033696 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029444
 protein coding gene Chr7:27573872-27576363 (-)
CAST/EiJ MGP_CASTEiJ_G0030984
 protein coding gene Chr7:20860474-20862943 (-)
CBA/J MGP_CBAJ_G0031612
 protein coding gene Chr7:29299880-29302349 (-)
DBA/2J MGP_DBA2J_G0031765
 protein coding gene Chr7:26263394-26265900 (-)
FVB/NJ MGP_FVBNJ_G0031722
 protein coding gene Chr7:26331426-26334092 (-)
LP/J MGP_LPJ_G0031846
 protein coding gene Chr7:27483332-27486640 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031757
 protein coding gene Chr7:28790980-28793450 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032422
 protein coding gene Chr7:26662537-26665006 (-)
PWK/PhJ MGP_PWKPhJ_G0030707
 protein coding gene Chr7:21265320-21267828 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030542
 protein coding gene Chr7:17667809-17670281 (-)
WSB/EiJ MGP_WSBEiJ_G0031091
 protein coding gene Chr7:26990923-26993425 (-)



Homology
more
  • Human Ortholog
    ZFP36, ZFP36 ring finger protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP36, ZFP36 ring finger protein
  • Synonyms
    G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
  • Links
    NCBI Gene ID: 7538
    UniProt: P26651

  • Chr Location
    19q13.2; chr19:39406847-39409407 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zfp36 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are normal at birth but soon develop myeloid hyperplasia, cachexia, patchy alopecia, dermatitis, arthritis, loss of adiposity, conjunctivitis, glomerular mesangial thickening and autoimmunity, with variable severity. All aspects of the syndrome are normalized by TNF antibody treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    136
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    923
  • Tissues
    110
  • cDNA Data
    57
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22695 NCBI Gene Model | MGI Sequence Detail 2473 C57BL/6J ±  kb
    transcript NM_011756 RefSeq | MGI Sequence Detail 1793 ZRU/MplStud  
    polypeptide P22893 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 9
      cDNA 61
      Primer pair 5
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15295, MGD-MRK-15877, MGD-MRK-15932
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 33
      Phenotypes 86
    • Earliest
      J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
    • Latest
      J:360985 Morel KL, et al., Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice. J Clin Invest. 2024 Nov 19;135(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory