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Zfp36 Gene Detail
Summary
  • Symbol
    Zfp36
  • Name
    zinc finger protein 36
  • Synonyms
    Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36
  • Feature Type
    protein coding gene
  • IDs
    MGI:99180
    NCBI Gene: 22695
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28076208-28078680 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.72 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99180
 protein coding gene Chr7:28076208-28079678 (-)
129S1/SvImJ ENSMUSG00200042313
 protein coding gene Chr7:17862029-17865498 (-)
A/J ENSMUSG00195048551
 protein coding gene Chr7:20535228-20538697 (-)
AKR/J ENSMUSG00220047546
 protein coding gene Chr7:23947230-23950700 (+)
BALB/cJ ENSMUSG00180045953
 protein coding gene Chr7:18594766-18598234 (-)
C3H/HeJ ENSMUSG00175047318
 protein coding gene Chr7:19630400-19633868 (-)
C57BL/6NJ ENSMUSG00215053782
 protein coding gene Chr7:17766019-17769488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029444
 protein coding gene Chr7:27573872-27576363 (-)
CAST/EiJ ENSTCUG00005050229
 protein coding gene Chr7:19552213-19555684 (-)
CBA/J ENSMUSG00210051462
 protein coding gene Chr7:18814997-18818465 (-)
DBA/2J ENSMUSG00185047567
 protein coding gene Chr7:21927688-21931157 (-)
FVB/NJ ENSMUSG00205049016
 protein coding gene Chr7:18600466-18603936 (-)
JF1/MsJ ENSUMUG00000018481
 protein coding gene Chr7:26329030-26332503 (-)
LP/J ENSMUSG00230051738
 protein coding gene Chr7:27098222-27101691 (-)
NOD/ShiLtJ ENSMUSG00190049299
 protein coding gene Chr7:18261982-18265451 (-)
NZO/HlLtJ ENSMUSG00225024384
 protein coding gene Chr7:25941350-25944819 (-)
PWK/PhJ ENSLUMG00010048528
 protein coding gene Chr7:18292946-18296420 (-)
SPRET/EiJ ENSMSPG00010040475
 protein coding gene Chr7:17652655-17655439 (-)
WSB/EiJ ENSIUOG00005053331
 protein coding gene Chr7:12522365-12525834 (-)



Homology
more
  • Human Ortholog
    ZFP36, ZFP36 zinc finger CCCH-type
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP36, ZFP36 zinc finger CCCH-type
  • Synonyms
    G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
  • Links
    NCBI Gene ID: 7538
    UniProt: P26651

  • Chr Location
    19q13.2; chr19:39406847-39409407 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zfp36 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are normal at birth but soon develop myeloid hyperplasia, cachexia, patchy alopecia, dermatitis, arthritis, loss of adiposity, conjunctivitis, glomerular mesangial thickening and autoimmunity, with variable severity. All aspects of the syndrome are normalized by TNF antibody treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    181
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    113
  • cDNA Data
    57
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22695 NCBI Gene Model | MGI Sequence Detail 2473 C57BL/6J ±  kb
    transcript NM_011756 RefSeq | MGI Sequence Detail 1793 ZRU/MplStud  
    polypeptide P22893 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      Genomic 9
      cDNA 61
      Primer pair 6
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15295, MGD-MRK-15877, MGD-MRK-15932
    References
    more
    • Summaries
      All 201
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 36
      Phenotypes 90
    • Earliest
      J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
    • Latest
      J:387831 Zhao Q, et al., Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. Cell Res. 2025 Feb;35(2):97-116
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory