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Zfp36
Gene Detail
Symbol

Name
ID
Zfp36
zinc finger protein 36
MGI:99180
Synonyms
Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:28376784-28379255 bp, - strand
From VEGA annotation of GRCm38

  2472 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2558  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Zfp36

Human
homologs
Human Homolog ZFP36, ZFP36 ring finger protein
NCBI Gene ID 7538
neXtProt AC  NX_P26651
Human Synonyms  G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
Human Chr (Location)  19q13.1; chr19:39406847-39409412 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes are normal at birth but soon develop myeloid hyperplasia, cachexia, patchy alopecia, dermatitis, arthritis, loss of adiposity, conjunctivitis, glomerular mesangial thickening and autoimmunity, with variable severity. All aspects of the syndrome are normalized by TNF antibody treatment.
 
Human Diseases Modeled Using Mouse Zfp36 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zfp36 interacts with 131 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process 3'-UTR-mediated mRNA stabilization, intracellular signal transduction, ...
Component cytoplasm, cytoplasmic stress granule, ...
Function 14-3-3 protein binding, AU-rich element binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (199)    Tissues (98)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
Northern blot 9
RT-PCR 146
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) Genomic(9) cDNA(60) Primer pair(5) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021115 (Evidence)
Ensembl Gene ModelENSMUSG00000044786 (Evidence)
Entrez Gene22695 (Evidence)
UniGene389856
DFCITC1574344, TC1749760
DoTSDT.101342640, DT.101384237, DT.99867541
NIA Mouse Gene IndexU028323
PDB1M9O
Consensus CDS ProjectCCDS21041.1
International Mouse Knockout Project StatusZfp36
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021115 VEGA Gene Model | MGI Sequence Detail 2472 C57BL/6J ±  kb
transcript OTTMUST00000049971 VEGA | MGI Sequence Detail 1792 Not Applicable 
polypeptide OTTMUSP00000023255 VEGA | MGI Sequence Detail 319 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(5 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000571 Zinc finger, CCCH-type
Protein Ontology PR:000017639 tristetraprolin
References
(Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:214114 Bollmann F, et al., Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-alpha expression. J Biol Chem. 2014 May 30;289(22):15653-65
All references(103)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15295, MGD-MRK-15877, MGD-MRK-15932

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory