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Zfp36 Gene Detail
Summary
  • Symbol
    Zfp36
  • Name
    zinc finger protein 36
  • Synonyms
    Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36
  • Feature Type
    protein coding gene
  • IDs
    MGI:99180
    NCBI Gene: 22695
  • Gene Overview
    MyGene.info: ZFP36
Location & Maps
more
  • Sequence Map
    Chr7:28376784-28380253 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      3470 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.72 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ZFP36, ZFP36 ring finger protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ZFP36, ZFP36 ring finger protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
  • Links
    NCBI Gene ID: 7538
    neXtProt AC: NX_P26651

  • Chr Location
    19q13.1; chr19:39406847-39409412 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Zfp36 mouse models

Human Disease Mouse Models
       Rheumatoid Arthritis; RA   OMIM: 180300 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 5 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are normal at birth but soon develop myeloid hyperplasia, cachexia, patchy alopecia, dermatitis, arthritis, loss of adiposity, conjunctivitis, glomerular mesangial thickening and autoimmunity, with variable severity. All aspects of the syndrome are normalized by TNF antibody treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    84
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    199
  • Tissues
    98
  • cDNA Data
    56
  • Literature Summary
    10
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021115 VEGA Gene Model | MGI Sequence Detail 3470 C57BL/6J ±  kb
transcript OTTMUST00000049971 VEGA | MGI Sequence Detail 2790 Not Applicable  
polypeptide OTTMUSP00000023255 VEGA | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    Genomic 9
    cDNA 60
    Primer pair 5
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15295, MGD-MRK-15877, MGD-MRK-15932
References
more
  • Summaries
    All 111
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 23
    Phenotypes 37
  • Earliest
    J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
  • Latest
    J:233888 Nowotarski SL, et al., Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Amino Acids. 2016 May 19;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory