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Xdh
Gene Detail
Symbol

Name
ID
Xdh
xanthine dehydrogenase
MGI:98973
Synonyms
xanthine oxidase, XO, Xor, Xox1, Xox-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:73883908-73950182 bp, - strand
From Ensembl annotation of GRCm38

  66275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: xanthine dehydrogenase
Gene Tree: Xdh

Human
homologs
Human Homolog XDH, xanthine dehydrogenase
NCBI Gene ID 7498
neXtProt AC  NX_P47989
Human Synonyms  XO, XOR
Human Chr (Location)  2p23.1; chr2:31334322-31414745 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human XDH
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele are small and die prematurely while heterozygous females show a lactation defect. Most homozygotes for another null allele die within the first month of renal failure associated with uric acid depletion, renal tubular damage, inflammation, fibrosis and oxidative stress.
 
Interactions
Xdh interacts with 113 markers (Mir15a, Mir29b-2, Mir30b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (103)    Tissues (99)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
RT-PCR 4
cDNA source data(105)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(121) Genomic(11) cDNA(107) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024066 (Evidence)
Entrez Gene22436 (Evidence)
UniGene11223
DFCITC1581763, TC1597502
DoTSDT.101735203, DT.50316624, DT.99853960, DT.99853961
NIA Mouse Gene IndexU038047
EC1.17.1.4, 1.17.3.2
Consensus CDS ProjectCCDS28967.1
International Mouse Knockout Project StatusXdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024066 Ensembl Gene Model | MGI Sequence Detail 66275 C57BL/6J ±  kb
transcript ENSMUST00000024866 Ensembl | MGI Sequence Detail 4587 Not Applicable 
polypeptide ENSMUSP00000024866 Ensembl | MGI Sequence Detail 1335 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(3) UniProt(13)
Polymorphisms
RFLP(5) : SNPs within 2kb(493 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002888 [2Fe-2S]-binding
InterPro IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
InterPro IPR001041 2Fe-2S ferredoxin-type domain
InterPro IPR016208 Aldehyde oxidase/xanthine dehydrogenase
InterPro IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
InterPro IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
InterPro IPR012675 Beta-grasp domain
InterPro IPR005107 CO dehydrogenase flavoprotein, C-terminal
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR016167 FAD-binding, type 2, subdomain 1
InterPro IPR002346 Molybdopterin dehydrogenase, FAD-binding
InterPro IPR022407 Oxidoreductase, molybdopterin binding site
InterPro IPR014309 Xanthine dehydrogenase, molybdopterin binding subunit
InterPro IPR014307 Xanthine dehydrogenase, small subunit
Protein Ontology PR:000017477 xanthine dehydrogenase/oxidase
References
(Earliest) J:6662 Holmes RS, et al., Liver aldehyde oxidase and xanthine oxidase genetics in the mouse. Anim Blood Groups Biochem Genet. 1981;12(3):193-9
(Latest) J:201238 Ko EA, et al., Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1042-52
All references(58)
Other
accession IDs
MGD-MRK-15471, MGD-MRK-15798, MGD-MRK-15799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory