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Xdh
Gene Detail
 Symbol
Name
ID
Xdh
xanthine dehydrogenase
MGI:98973
Synonyms xanthine oxidase, XO, Xor, Xox1, Xox-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:73883908-73950182 bp, - strand
From NCBI annotation of GRCm38

  66275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: xanthine dehydrogenase
Gene Tree: Xdh

Human
homologs
Human Homolog XDH, xanthine dehydrogenase
NCBI Gene ID 7498
neXtProt AC  NX_P47989
Human Synonyms  XO, XOR
Human Chr (Location)  2p23.1; chr2:31334322-31414745 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human XDH
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Chemically induced(1)
 
Homozygotes for a null allele are small and die prematurely while heterozygous females show a lactation defect. Most homozygotes for another null allele die within the first month of renal failure associated with uric acid depletion, renal tubular damage, inflammation, fibrosis and oxidative stress.
 
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, bone resorption, ...
Component cytoplasm, cytosol, ...
Function 2 iron, 2 sulfur cluster binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (103)    Tissues (99)    Images (7)
Theiler Stages: 9, 11, 13, 15, 22, 23
Assay TypeResults
RNA in situ 99
RT-PCR 4
cDNA source data(105)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(121) Genomic(11) cDNA(107) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024066 (Evidence)
Entrez Gene22436 (Evidence)
UniGene11223
DFCITC1581763, TC1597502
DoTSDT.101735203, DT.50316624, DT.99853960, DT.99853961
NIA Mouse Gene IndexU038047
EC1.17.1.4, 1.17.3.2
Consensus CDS ProjectCCDS28967.1
International Mouse Knockout Project StatusXdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22436 NCBI Gene Model | MGI Sequence Detail 66275 C57BL/6J ±  kb
transcript NM_011723 RefSeq | MGI Sequence Detail 4623 C57BL/6 
polypeptide Q00519 UniProt | EBI | MGI Sequence Detail 1335 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(3) UniProt(7)
Polymorphisms RFLP(5) : SNPs within 2kb(493 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002888 [2Fe-2S]-binding
InterPro IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
InterPro IPR001041 2Fe-2S ferredoxin-type domain
InterPro IPR016208 Aldehyde oxidase/xanthine dehydrogenase
InterPro IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
InterPro IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
InterPro IPR012675 Beta-grasp domain
InterPro IPR005107 CO dehydrogenase flavoprotein, C-terminal
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR016167 FAD-binding, type 2, subdomain 1
InterPro IPR002346 Molybdopterin dehydrogenase, FAD-binding
InterPro IPR022407 Oxidoreductase, molybdopterin binding site
InterPro IPR014309 Xanthine dehydrogenase, molybdopterin binding subunit
InterPro IPR014307 Xanthine dehydrogenase, small subunit
Protein Ontology PR:000017477 xanthine dehydrogenase/oxidase
Graphical View of Protein Domain Structure
References (Earliest) J:6662 Holmes RS, et al., Liver aldehyde oxidase and xanthine oxidase genetics in the mouse. Anim Blood Groups Biochem Genet. 1981;12(3):193-9
(Latest) J:187825 Chen Q, et al., Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice. PLoS One. 2012;7(6):e37149
All references(57)
Other
accession IDs
MGD-MRK-15471, MGD-MRK-15798, MGD-MRK-15799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory