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Wap
Gene Detail
Symbol

Name
ID
Wap
whey acidic protein
MGI:98943
Feature Type
protein coding gene
Genetic Map
Chromosome 11
4.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:6635482-6638637 bp, - strand
From VEGA annotation of GRCm38

  3156 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137242  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: four-disulfide core domain protein, WAP type
Gene Tree: Wap

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change in WAP protein in YBR versus other strains.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Wap interacts with 37 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process negative regulation of peptidase activity
Component extracellular region
Function nutrient reservoir activity, peptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(236)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(245) Genomic(5) cDNA(236) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005118 (Evidence)
Ensembl Gene ModelENSMUSG00000000381 (Evidence)
Entrez Gene22373 (Evidence)
UniGene268094
DoTSDT.55191380, DT.99841184
NIA Mouse Gene IndexU032498
Consensus CDS ProjectCCDS24424.1
International Mouse Knockout Project StatusWap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005118 VEGA Gene Model | MGI Sequence Detail 3156 C57BL/6J ±  kb
transcript OTTMUST00000011455 VEGA | MGI Sequence Detail 551 Not Applicable 
polypeptide OTTMUSP00000005333 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008197 Whey acidic protein-type 4-disulphide core
Protein Ontology PR:000017467 whey acidic protein
References
(Earliest) J:6634 Piletz JE, et al., Biochemical characterization of a novel whey protein from murine milk. J Biol Chem. 1981 Nov 25;256(22):11509-16
(Latest) J:213526 Schmidt JW, et al., Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol. 2014 Apr;34(7):1363-77
All references(57)
Other
accession IDs
MGD-MRK-15427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory