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U2af2
Gene Detail
Symbol

Name
ID
U2af2
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
MGI:98886
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.93 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:5062143-5079945 bp, + strand
From Ensembl annotation of GRCm38

  17803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110853  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: U2AF2
Gene Tree: U2af2

Human
homologs
U2AF2, U2 small nuclear RNA auxiliary factor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11338
neXtProt AC: NX_P26368

Human Synonyms: U2AF65

Human Chr (Location): 19q13.42; chr19:55654050-55674716 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(118) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
U2af2 interacts with 99 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process mRNA processing, negative regulation of mRNA splicing, via spliceosome, ...
Component nuclear speck, nucleoplasm, ...
Function C2H2 zinc finger domain binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (38)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
RT-PCR 2
cDNA source data(115)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase u2af2 ; ZFIN u2af2b    NEW 
Molecular
reagents
All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030435 (Evidence)
Entrez Gene 22185 (Evidence)
UniGene 360389
DFCI TC1574309, TC1590656, TC1592814, TC1593735
DoTS DT.101397162, DT.102558884, DT.55145369, DT.97374854, DT.97407574
NIA Mouse Gene Index U007623, U024000
PDB 3V4M, 2M52, 4RU2
Consensus CDS Project CCDS57476.1
International Mouse Phenotyping Consortium Status U2af2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030435 Ensembl Gene Model | MGI Sequence Detail 17803 C57BL/6J ±  kb
transcript ENSMUST00000005041 Ensembl | MGI Sequence Detail 2202 Not Applicable 
polypeptide ENSMUSP00000005041 Ensembl | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
InterPro IPR006529 U2 snRNP auxilliary factor, large subunit, splicing factor
Protein Ontology PR:000016946 splicing factor U2AF 65 kDa subunit
References
(Earliest) J:872 Sailer A, et al., Cloning and sequencing of the murine homologue of the human splicing factor U2AF65. Nucleic Acids Res. 1992 May 11;20(9):2374
(Latest) J:197742 Pedrotti S, et al., The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 2012 Feb;40(3):1021-32
All references(36)
Other
accession IDs
MGD-MRK-15323

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory