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U2af2
Gene Detail
Symbol

Name
ID
U2af2
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
MGI:98886
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.93 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:5062143-5079945 bp, + strand
From NCBI annotation of GRCm38

  17803 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110853  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: U2af2

Human
homologs
Human Homolog U2AF2, U2 small nuclear RNA auxiliary factor 2
NCBI Gene ID 11338
neXtProt AC  NX_P26368
Human Synonyms  U2AF65
Human Chr (Location)  19q13.42; chr19:55654050-55674716 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(118) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
U2af2 interacts with 99 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process mRNA processing, negative regulation of mRNA splicing, via spliceosome, ...
Component nuclear speck, nucleus, ...
Function C2H2 zinc finger domain binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (38)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
RT-PCR 2
cDNA source data(115)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030435 (Evidence)
Entrez Gene22185 (Evidence)
UniGene360389
DFCITC1574309, TC1590656, TC1592814, TC1593735
DoTSDT.101397162, DT.102558884, DT.55145369, DT.97374854, DT.97407574
NIA Mouse Gene IndexU007623, U024000
PDB3V4M, 2M52
Consensus CDS ProjectCCDS57476.1
International Mouse Knockout Project StatusU2af2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22185 NCBI Gene Model | MGI Sequence Detail 17803 C57BL/6J ±  kb
transcript NM_001205231 RefSeq | MGI Sequence Detail 2202 C57BL/6 
polypeptide P26369 UniProt | EBI | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
InterPro IPR006529 U2 snRNP auxilliary factor, large subunit, splicing factor
Protein Ontology PR:000016946 splicing factor U2AF 65 kDa subunit
Graphical View of Protein Domain Structure
References
(Earliest) J:872 Sailer A, et al., Cloning and sequencing of the murine homologue of the human splicing factor U2AF65. Nucleic Acids Res. 1992 May 11;20(9):2374
(Latest) J:197742 Pedrotti S, et al., The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 2012 Feb;40(3):1021-32
All references(38)
Other
accession IDs
MGD-MRK-15323

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory