U2af2
Gene Detail

Symbol Name ID

U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 MGI:98886

Feature Type

protein coding gene

Genetic Map

Chromosome 7

2.93 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:5062143-5079945 bp, + strand From NCBI annotation of GRCm38   17803 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110853  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: U2af2

Human homologs

Human Homolog		U2AF2, U2 small nuclear RNA auxiliary factor 2
NCBI Gene ID		11338
neXtProt AC		NX_P26368
Human Synonyms		U2AF65
Human Chr (Location)		19q13.42; chr19:56165416-56186082 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(119) : Targeted(1) Gene trapped(118)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	mRNA processing, negative regulation of mRNA splicing, via spliceosome, ...
Component	nuclear speck, nucleus, ...
Function	C2H2 zinc finger domain binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (119)    Tissues (38)    Images (26)
Theiler Stages: 21, 23, 28

Assay Type	Results
RNA in situ	117
RT-PCR	2

cDNA source data(115)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(116) cDNA(115) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030435 (Evidence)
Entrez Gene	22185 (Evidence)
UniGene	360389
DFCI	TC1574309, TC1590656, TC1592814, TC1593735
DoTS	DT.101397162, DT.102558884, DT.55145369, DT.97374854, DT.97407574
NIA Mouse Gene Index	U007623, U024000
PDB	3V4M
Consensus CDS Project	CCDS57476.1
International Mouse Knockout Project Status	U2af2

Sequences

Length	Strain/Species
genomic	22185	NCBI Gene Model | MGI Sequence Detail	17803	C57BL/6J
transcript	NM_001205231	RefSeq | MGI Sequence Detail	2202	C57BL/6
polypeptide	P26369	UniProt | EBI | MGI Sequence Detail	475	Not Applicable

All sequences(34) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR006529	U2 snRNP auxilliary factor, large subunit, splicing factor
Protein Ontology	PR:000016946	splicing factor U2AF 65 kDa subunit

Graphical View of Protein Domain Structure

References

(Earliest) J:872 Sailer A, et al., Cloning and sequencing of the murine homologue of the human splicing factor U2AF65. Nucleic Acids Res. 1992 May 11;20(9):2374
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(37)

Other accession IDs

MGD-MRK-15323