Tek
Gene Detail

Symbol Name ID

Tek endothelial-specific receptor tyrosine kinase MGI:98664

Synonyms

Cd202b, Hyk, tie-2, Tie2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

43.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr4:94739289-94874976 bp, + strand From VEGA annotation of GRCm38   135688 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein-tyrosine kinase, receptor type tie
Gene Tree: Tek

Human homologs

Human Homolog		TEK, TEK tyrosine kinase, endothelial
NCBI Gene ID		7010
neXtProt AC		NX_Q02763
Human Synonyms		CD202B, TIE2, TIE-2, VMCM, VMCM1
Human Chr (Location)		9p21; chr9:27109147-27230172 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TEK

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.

 

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	angiogenesis, cell-cell adhesion, ...
Component	actin filament, apical plasma membrane, ...
Function	ATP binding, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (136 records)
Data Summary: Results (188)    Tissues (94)    Images (33)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	79
Northern blot	44
Western blot	7
RT-PCR	54

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) Genomic(3) cDNA(55) Primer pair(10) Other(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000007859 (Evidence)
Ensembl Gene Model	ENSMUSG00000006386 (Evidence)
Entrez Gene	21687 (Evidence)
UniGene	14313
DFCI	TC1582308, TC1593038, TC1616453
DoTS	DT.101376754, DT.50316930, DT.55189997, DT.94260595
NIA Mouse Gene Index	U004508
EC	2.7.10.1
Consensus CDS Project	CCDS18361.1
International Mouse Knockout Project Status	Tek

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007859	VEGA Gene Model | MGI Sequence Detail	135688	C57BL/6J
transcript	OTTMUST00000017987	VEGA | MGI Sequence Detail	4654	Not Applicable
polypeptide	OTTMUSP00000008261	VEGA | MGI Sequence Detail	1123	Not Applicable

All sequences(41) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(585 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR018941	Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
Protein Ontology	PR:000002032	angiopoietin-1 receptor

References

(Earliest) J:1682 Dumont DJ, et al., tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug;7(8):1471-80
(Latest) J:195430 Fantin A, et al., NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood. 2013 Mar 21;121(12):2352-62
All references(206)

Other accession IDs

MGD-MRK-14991, MGD-MRK-16702, MGD-MRK-18601, MGI:2140157