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Tek
Gene Detail
 Symbol
Name
ID
Tek
endothelial-specific receptor tyrosine kinase
MGI:98664
Synonyms Cd202b, Hyk, tie-2, Tie2
Feature Type protein coding gene
Genetic Map
Chromosome 4
43.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:94739289-94874976 bp, + strand
From VEGA annotation of GRCm38

  135688 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein-tyrosine kinase, receptor type tie
Gene Tree: Tek

Human
homologs
Human Homolog TEK, TEK tyrosine kinase, endothelial
NCBI Gene ID 7010
neXtProt AC  NX_Q02763
Human Synonyms  CD202B, TIE2, TIE-2, VMCM, VMCM1
Human Chr (Location)  9p21; chr9:27109149-27230174 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TEK
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.
 
Interactions
Tek interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process angiogenesis, cell-matrix adhesion, ...
Component actin filament, apical plasma membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (142 records)
Data Summary: Results (188)    Tissues (97)    Images (33)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 79
Northern blot 44
Western blot 7
RT-PCR 54
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(75) Genomic(3) cDNA(55) Primer pair(10) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000007859 (Evidence)
Ensembl Gene ModelENSMUSG00000006386 (Evidence)
Entrez Gene21687 (Evidence)
UniGene14313
DFCITC1582308, TC1593038, TC1616453
DoTSDT.101376754, DT.50316930, DT.55189997, DT.94260595
NIA Mouse Gene IndexU004508
EC2.7.10.1
Consensus CDS ProjectCCDS18361.1, CCDS71421.1
International Mouse Knockout Project StatusTek
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007859 VEGA Gene Model | MGI Sequence Detail 135688 C57BL/6J ±  kb
transcript OTTMUST00000017987 VEGA | MGI Sequence Detail 4654 Not Applicable 
polypeptide OTTMUSP00000008261 VEGA | MGI Sequence Detail 1123 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
Protein Ontology PR:000002032 angiopoietin-1 receptor
References (Earliest) J:1682 Dumont DJ, et al., tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug;7(8):1471-80
(Latest) J:210349 Mainigi MA, et al., Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014 Feb;90(2):26
All references(215)
Other
accession IDs
MGD-MRK-14991, MGD-MRK-16702, MGD-MRK-18601, MGI:2140157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory