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Tek
Gene Detail
Symbol

Name
ID
Tek
endothelial-specific receptor tyrosine kinase
MGI:98664
Synonyms
Cd202b, Hyk, tie-2, Tie2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
43.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:94739289-94874976 bp, + strand
From VEGA annotation of GRCm38

  135688 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:397  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TEK
Protein SuperFamily: protein-tyrosine kinase, receptor type tie
Gene Tree: Tek

Human
homologs
TEK, TEK tyrosine kinase, endothelial
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7010
neXtProt AC: NX_Q02763

Human Synonyms: CD202B, TIE2, TIE-2, VMCM, VMCM1

Human Chr (Location): 9p21; chr9:27109141-27230178 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TEK

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.
 
Interactions
Tek interacts with 246 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (87 annotations)
Process angiogenesis, cell-matrix adhesion, ...
Component actin filament, apical plasma membrane, ...
Function ATP binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (152 records)
Data Summary: Results (188)    Tissues (97)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 79
Northern blot 44
Western blot 7
RT-PCR 54
cDNA source data(54)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TEK ; Xenbase tek ; ZFIN tek    NEW 
Molecular
reagents
All nucleic(75) Genomic(3) cDNA(55) Primer pair(10) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000007859 (Evidence)
Ensembl Gene Model ENSMUSG00000006386 (Evidence)
Entrez Gene 21687 (Evidence)
UniGene 14313
DFCI TC1582308, TC1593038, TC1616453
DoTS DT.101376754, DT.50316930, DT.55189997, DT.94260595
NIA Mouse Gene Index U004508
EC 2.7.10.1
Consensus CDS Project CCDS18361.1, CCDS71421.1, CCDS80122.1
International Mouse Phenotyping Consortium Status Tek
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007859 VEGA Gene Model | MGI Sequence Detail 135688 C57BL/6J ±  kb
transcript OTTMUST00000017987 VEGA | MGI Sequence Detail 4654 Not Applicable 
polypeptide OTTMUSP00000008261 VEGA | MGI Sequence Detail 1123 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR003961 Fibronectin type III
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002049 Laminin EGF domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
Protein Ontology PR:000002032 angiopoietin-1 receptor
References
(Earliest) J:1682 Dumont DJ, et al., tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug;7(8):1471-80
(Latest) J:219867 Busch K, et al., Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Nature. 2015 Feb 26;518(7540):542-6
All references(227)
Other
accession IDs
MGD-MRK-14991, MGD-MRK-16702, MGD-MRK-18601, MGI:2140157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory