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Trbv14 Gene Detail
Summary
  • Symbol
    Trbv14
  • Name
    T cell receptor beta, variable 14
  • Synonyms
    BV13S1, Gm16910
  • Feature Type
    gene segment
  • IDs
    MGI:98587
    NCBI Gene: 100124678
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41112101-41112550 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98587
 gene segment Chr6:41112079-41112550 (+)
129S1/SvImJ MGP_129S1SvImJ_G0002586
 gene segment Chr6:39615569-39616040 (+)
A/J MGP_AJ_G0002557
 gene segment Chr6:37889515-37889986 (+)
AKR/J MGP_AKRJ_G0002548
 gene segment Chr6:39094348-39094819 (+)
BALB/cJ MGP_BALBcJ_G0002543
 gene segment Chr6:38099712-38100183 (+)
C3H/HeJ MGP_C3HHeJ_G0002510
 gene segment Chr6:39115781-39116252 (+)
C57BL/6NJ MGP_C57BL6NJ_G0002684
 gene segment Chr6:40599772-40600243 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0002253
 gene segment Chr6:35679912-35680377 (+)
CAST/EiJ MGP_CASTEiJ_G0002495
 gene segment Chr6:39004767-39005241 (+)
CBA/J MGP_CBAJ_G0002509
 gene segment Chr6:42240747-42241218 (+)
DBA/2J MGP_DBA2J_G0002513
 gene segment Chr6:37701695-37702166 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0002592
 gene segment Chr6:39626659-39627130 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0002516
 gene segment Chr6:44485712-44486183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0002694
 gene segment Chr6:39069192-39069663 (+)
PWK/PhJ MGP_PWKPhJ_G0002455
 gene segment Chr6:37327707-37328179 (+)
SPRET/EiJ MGP_SPRETEiJ_G0002407
 gene segment Chr6:38764901-38765369 (+)
WSB/EiJ MGP_WSBEiJ_G0002511
 gene segment Chr6:38999414-38999886 (+)



Homology
more
  • Human Ortholog
    TRBV11-1, T cell receptor beta variable 11-1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRBV11-1, T cell receptor beta variable 11-1
  • Synonyms
    TCRBV11S1, TCRBV21S1, TRBV111
  • Links
    NCBI Gene ID: 28582
    UniProt: A0A0K0K1C0

  • Chr Location
    7q34; chr7:142407672-142408136 (+)  GRCh38
  • Human Ortholog
    TRBV11-2, T cell receptor beta variable 11-2
  • Synonyms
    TCRBV11S2, TCRBV21S3A2N2T, TRBV112
  • Links
    NCBI Gene ID: 28581
    UniProt: A0A584

  • Chr Location
    7q34; chr7:142433895-142434394 (+)  GRCh38
  • Human Ortholog
    TRBV11-3, T cell receptor beta variable 11-3
  • Synonyms
    TCRBV11S3, TCRBV21S2A2, TRBV113
  • Links
    NCBI Gene ID: 28580
    UniProt: A0A5A6

  • Chr Location
    7q34; chr7:142554836-142555318 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for either of two knock-out alleles exhibit decreased T cell number with virtually no production of Vbeta13-expressing T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    46
  • cDNA Data
    2
  • Literature Summary
    2
Sequences &
Gene Models
less
  • All Sequences
    24
  • RefSeq
    1
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 100124678 NCBI Gene Model | MGI Sequence Detail 450 C57BL/6J ±  kb
polypeptide A0A140T8L9 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less
  • All nucleic 13
    Genomic 3
    cDNA 7
    Primer pair 1
    Other 2
Other
Accession IDs
less
MGD-MRK-14879, MGI:4439834
References
more
  • Summaries
    All 19
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
  • Latest
    J:265349 Son CY, et al., Identification of the transgenic integration site in 2C T cell receptor transgenic mice. Transgenic Res. 2018 Oct;27(5):441-450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory