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Serpina1 Complex/Cluster/Region Detail
Summary
  • Symbol
    Serpina1
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1 cluster
  • Synonyms
    [a]1-antitrypsin, [a]1-PI, [a]1-proteinase inhibitor, Aat, alpha-1 antiproteinase, antitrypsin, Pre, Pre-1, Spi1, Spi-1
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:98376
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 12, cytoband E-F
  • Mapping Data
    99 experiments
Strain
Comparison
more
  • RFLP
    9
Human Diseases
more
  • Diseases
    2 with Serpina1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    14
  • Tissues
    8
  • cDNA Data
    12
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    Sequences &
    Gene Models
    less
    • All Sequences
      5
    Representative SequencesLengthStrain/SpeciesFlank
    transcript S70316 GenBank | ENA | DDBJ | MGI Sequence Detail 1373 M. saxicola  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 8
      cDNA 13
      Primer pair 2
    Other
    Accession IDs
    less
    MGD-MRK-1011, MGD-MRK-13600, MGD-MRK-13601, MGD-MRK-14520, MGD-MRK-14525
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 1
      Phenotypes 2
    • Earliest
      J:12960 SHREFFLER DC, INHERITANCE OF A SERUM PRE-ALBUMIN VARIANT IN THE MOUSE. Genetics. 1964 Apr;49:629-34
    • Latest
      J:320456 Deuse T, et al., Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2022091118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory