Sox10
Gene Detail

Symbol Name ID

Sox10 SRY-box containing gene 10 MGI:98358

Synonyms

Sox21

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr15:79154913-79164490 bp, - strand From NCBI annotation of GRCm38   9578 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox10

Human homologs

Human Homolog		SOX10, SRY (sex determining region Y)-box 10
NCBI Gene ID		6663
neXtProt AC		NX_P56693
Human Synonyms		DOM, PCWH, WS2E, WS4, WS4C
Human Chr (Location)		22q13.1; chr22:38368319-38380539 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human SOX10

Alleles and phenotypes

All alleles(14) : Targeted(9) Spontaneous(2) Chemically induced(1) Radiation induced(2)
 

Homozygotes for null mutations lack peripheral glial cells, melanocytes, and autonomic and enteric neurons, and die neonatally or sooner. Heterozygotes exhibit white spotting and megacolon.

 

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	cell differentiation, cell maturation, ...
Component	cytoplasm, extrinsic to mitochondrial outer membrane, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (258 records)
Data Summary: Results (464)    Tissues (144)    Images (135)
Theiler Stages: 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	404
In situ reporter (knock in)	35
Northern blot	12
RT-PCR	3

cDNA source data(157)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(173) Genomic(7) cDNA(159) Primer pair(2) Other(5)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000033006 (Evidence)
Entrez Gene	20665 (Evidence)
UniGene	276739
DFCI	TC1576355, TC1584493, TC1601628, TC1724911
DoTS	DT.91325371, DT.94413089, DT.94413090
NIA Mouse Gene Index	U036399
Consensus CDS Project	CCDS49668.1
International Mouse Knockout Project Status	Sox10

Sequences

Length	Strain/Species
genomic	20665	NCBI Gene Model | MGI Sequence Detail	9578	C57BL/6J
transcript	NM_011437	RefSeq | MGI Sequence Detail	2713	C57BL/6
polypeptide	Q04888	UniProt | EBI | MGI Sequence Detail	466	Not Applicable

All sequences(56) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
InterPro	IPR022151	Sox developmental protein N-terminal
Protein Ontology	PR:000015418	transcription factor SOX-10

Graphical View of Protein Domain Structure

References

(Earliest) J:13909 Lane PW, Dominant megacolon (Dom). Mouse News Lett. 1982;66:66
(Latest) J:194281 Silver DL, et al., The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. Dev Biol. 2013 Mar 15;375(2):172-81
All references(334)

Other accession IDs

MGD-MRK-14497, MGD-MRK-38228, MGD-MRK-8879, MGI:109184, MGI:94914