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Sox10
Gene Detail
 Symbol
Name
ID
Sox10
SRY (sex determining region Y)-box 10
MGI:98358
Synonyms Sox21
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr15:79154913-79164490 bp, - strand
From NCBI annotation of GRCm38

  9578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox10

Human
homologs
Human Homolog SOX10, SRY (sex determining region Y)-box 10
NCBI Gene ID 6663
neXtProt AC  NX_P56693
Human Synonyms  DOM, PCWH, WS2E, WS4, WS4C
Human Chr (Location)  22q13.1; chr22:37972312-37984532 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human SOX10
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(2) Radiation induced(3) Spontaneous(2) Targeted(10)
Genomic Mutations involving Sox10 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations lack peripheral glial cells, melanocytes, and autonomic and enteric neurons, and die neonatally or sooner. Heterozygotes exhibit white spotting and megacolon.
 
Interactions
Sox10 interacts with 146 markers (Mir15a, Mir25, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process cell differentiation, cell maturation, ...
Component cytoplasm, extrinsic component of mitochondrial outer membrane, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (291 records)
Data Summary: Results (759)    Tissues (308)    Images (245)
Theiler Stages: 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 21
RNA in situ 645
In situ reporter (knock in) 78
Northern blot 12
RT-PCR 3
cDNA source data(169)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(188) Genomic(7) cDNA(171) Primer pair(2) Other(8)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000033006 (Evidence)
Entrez Gene20665 (Evidence)
UniGene276739
DFCITC1576355, TC1584493, TC1601628, TC1724911
DoTSDT.91325371, DT.94413089, DT.94413090
NIA Mouse Gene IndexU036399
Consensus CDS ProjectCCDS49668.1
International Mouse Knockout Project StatusSox10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20665 NCBI Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
transcript NM_011437 RefSeq | MGI Sequence Detail 2713 C57BL/6 
polypeptide Q04888 UniProt | EBI | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022151 Sox developmental protein N-terminal
Protein Ontology PR:000015418 transcription factor SOX-10
Graphical View of Protein Domain Structure
References (Earliest) J:13909 Lane PW, Dominant megacolon (Dom). Mouse News Lett. 1982;66:66
(Latest) J:208432 Schwarz D, et al., Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77
All references(377)
Other
accession IDs
MGD-MRK-14497, MGD-MRK-38228, MGD-MRK-8879, MGI:109184, MGI:94914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory