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Sox10 Gene Detail
Summary
  • Symbol
    Sox10
  • Name
    SRY (sex determining region Y)-box 10
  • Synonyms
    gt, Sox21
  • Feature Type
    protein coding gene
  • IDs
    MGI:98358
    NCBI Gene: 20665
  • Gene Overview
    MyGene.info: SOX10
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79154913-79164490 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98358
protein coding gene Chr15:79154908-79165240 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022067
protein coding gene Chr15:79412083-79421651 (-)
A/J MGP_AJ_G0022028
protein coding gene Chr15:76670274-76679879 (-)
AKR/J MGP_AKRJ_G0022003
protein coding gene Chr15:78796045-78805650 (-)
BALB/cJ MGP_BALBcJ_G0022034
protein coding gene Chr15:76642052-76651655 (-)
C3H/HeJ MGP_C3HHeJ_G0021805
protein coding gene Chr15:78795633-78805237 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022477
protein coding gene Chr15:82530999-82540572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020007
protein coding gene Chr15:73151250-73160616 (-)
CAST/EiJ MGP_CASTEiJ_G0021326
protein coding gene Chr15:79493610-79503133 (-)
CBA/J MGP_CBAJ_G0021770
protein coding gene Chr15:85082522-85092127 (-)
DBA/2J MGP_DBA2J_G0021899
protein coding gene Chr15:76147843-76157448 (-)
FVB/NJ MGP_FVBNJ_G0021877
protein coding gene Chr15:75172472-75182891 (-)
LP/J MGP_LPJ_G0021967
protein coding gene Chr15:79602796-79612370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021897
protein coding gene Chr15:90232710-90242277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022491
protein coding gene Chr15:78818733-78828300 (-)
PWK/PhJ MGP_PWKPhJ_G0021068
protein coding gene Chr15:76154943-76164610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020905
protein coding gene Chr15:78625035-78634464 (-)
WSB/EiJ MGP_WSBEiJ_G0021378
protein coding gene Chr15:79201860-79211435 (-)



Homology
more
  • Human Ortholog
    SOX10, SRY-box 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOX10, SRY-box 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DOM, PCWH, WS2E, WS4, WS4C
  • Links
    NCBI Gene ID: 6663
    neXtProt AC: NX_P56693
    UniProt: P56693

  • Chr Location
    22q13.1; chr22:37972312-37984532 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5055
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SOX10
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Sox10 mouse models; 3 with human SOX10 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    101 phenotypes from 16 alleles in 21 genetic backgrounds
    22 phenotypes from multigenic genotypes
    7 images
    124 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null mutations lack peripheral glial cells, melanocytes, and autonomic and enteric neurons, and die neonatally or sooner. Heterozygotes exhibit white spotting and megacolon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20665 NCBI Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
    transcript NM_011437 RefSeq | MGI Sequence Detail 2713 C57BL/6  
    polypeptide Q04888 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 206
      Genomic 7
      cDNA 176
      Primer pair 5
      Other 18

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10325, MGD-MRK-14497, MGD-MRK-38228, MGD-MRK-8879, MGI:109184, MGI:94914, MGI:95866
    References
    more
    • Summaries
      All 554
      Developmental Gene Expression 416
      Diseases 4
      Gene Ontology 24
      Phenotypes 124
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:266214 Garg A, et al., FGF-induced Pea3 transcription factors program the genetic landscape for cell fate determination. PLoS Genet. 2018 Sep;14(9):e1007660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory