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Sox10
Gene Detail
Symbol

Name
ID
Sox10
SRY (sex determining region Y)-box 10
MGI:98358
Synonyms
Sox21
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr15:79154913-79164490 bp, - strand
From Ensembl annotation of GRCm38

  9578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5055  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOX10
Gene Tree: Sox10

Human
homologs
SOX10, SRY (sex determining region Y)-box 10
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6663
neXtProt AC: NX_P56693

Human Synonyms: DOM, PCWH, WS2E, WS4, WS4C

Human Chr (Location): 22q13.1; chr22:37972312-37984532 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human SOX10

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(2) Radiation induced(3) Spontaneous(2) Targeted(10)
Genomic Mutations involving Sox10 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations lack peripheral glial cells, melanocytes, and autonomic and enteric neurons, and die neonatally or sooner. Heterozygotes exhibit white spotting and megacolon.
 
Phenotype Images(2)
Interactions
Sox10 interacts with 146 markers (Mir15a, Mir25, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process cell differentiation, cell maturation, ...
Component cytoplasm, extrinsic component of mitochondrial outer membrane, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (318 records)
Data Summary: Results (801)    Tissues (317)    Images (271)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 680
In situ reporter (knock in) 83
Northern blot 12
RT-PCR 3
cDNA source data(169)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SOX10 ; Xenbase sox10 ; ZFIN sox10    NEW 
Molecular
reagents
All nucleic(192) Genomic(7) cDNA(172) Primer pair(3) Other(10)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000033006 (Evidence)
Entrez Gene 20665 (Evidence)
UniGene 276739
DFCI TC1576355, TC1584493, TC1601628, TC1724911
DoTS DT.91325371, DT.94413089, DT.94413090
NIA Mouse Gene Index U036399
Consensus CDS Project CCDS49668.1
International Mouse Phenotyping Consortium Status Sox10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033006 Ensembl Gene Model | MGI Sequence Detail 9578 C57BL/6J ±  kb
transcript ENSMUST00000040019 Ensembl | MGI Sequence Detail 2713 Not Applicable 
polypeptide ENSMUSP00000039466 Ensembl | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022151 Sox developmental protein N-terminal
Protein Ontology PR:000015418 transcription factor SOX-10
References
(Earliest) J:13909 Lane PW, Dominant megacolon (Dom). Mouse News Lett. 1982;66:66
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(405)
Other
accession IDs
MGD-MRK-14497, MGD-MRK-38228, MGD-MRK-8879, MGI:109184, MGI:94914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory