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Rras
Gene Detail
 Symbol
Name
ID
Rras
Harvey rat sarcoma oncogene, subgroup R
MGI:98179
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr7:45017978-45021646 bp, + strand
From VEGA annotation of GRCm38

  3669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4565  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ras protein
Gene Tree: Rras

Human
homologs
Human Homolog RRAS, related RAS viral (r-ras) oncogene homolog
NCBI Gene ID 6237
neXtProt AC  NX_P10301
Human Chr (Location)  19q13.33; chr19:49635295-49640143 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene-trapped allele exhibit enhanced neointimal thickening in response to arterial injury, increased angiogenesis in matrigel plugs and aortic ring cultures, and increased neovascularization of tumor implants, and decreased B-cell and increased T-cell population percentages.
 
Interactions
Rras interacts with 107 markers (Mir15a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process GTP catabolic process, negative regulation of cell migration, ...
Component extracellular vesicular exosome, membrane, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (58)    Tissues (53)    Images (1)
Theiler Stages: 21, 23, 25, 28
Assay TypeResults
Immunohistochemistry 7
Western blot 5
RT-PCR 46
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022547 (Evidence)
Ensembl Gene ModelENSMUSG00000038387 (Evidence)
Entrez Gene20130 (Evidence)
UniGene389894
DFCITC1580579
DoTSDT.534801, DT.94187253
NIA Mouse Gene IndexU008061
Consensus CDS ProjectCCDS21226.1
International Mouse Knockout Project StatusRras
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022547 VEGA Gene Model | MGI Sequence Detail 3669 C57BL/6J ±  kb
transcript OTTMUST00000054007 VEGA | MGI Sequence Detail 977 Not Applicable 
polypeptide OTTMUSP00000025720 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000014301 ras-related protein R-Ras
References (Earliest) J:23421 Sakaguchi AY, et al., R-ras: A member of the ras family on human Chromosome 19. Am J Hum Genet. 1986;39(Suppl):A167 (Abstr.)
(Latest) J:206656 Worzfeld T, et al., Genetic dissection of plexin signaling in vivo. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2194-9
All references(56)
Other
accession IDs
MGD-MRK-14208, MGI:2142000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory