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Rom1 Gene Detail
Summary
  • Symbol
    Rom1
  • Name
    rod outer segment membrane protein 1
  • Synonyms
    M101156, Rgsc1156, Rom-1, Tspan23
  • Feature Type
    protein coding gene
  • IDs
    MGI:97998
    NCBI Gene: 19881
  • Gene Overview
    MyGene.info: ROM1
Location & Maps
more
  • Genetic Map
    Chromosome 19, 6.03 cM
  • Mapping Data
    4 experiments
Homology
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  • Human Ortholog
    ROM1, retinal outer segment membrane protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ROM1, retinal outer segment membrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ROM, ROSP1, RP7, TSPAN23
  • Links
    NCBI Gene ID: 6094
    neXtProt AC: NX_Q03395

  • Chr Location
    11q12.3; chr11:62612741-62615120 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ROM1 associations

Human Disease Mouse Models
       Retinitis Pigmentosa 7; RP7   OMIM: 608133
Retinitis Pigmentosa; RP   OMIM: 268000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Homozygous null mutants exhibit large retinal discs, disorganized outer segments, gradual loss of rod photoreceptors by apoptosis, and diminished photo responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19881 NCBI Gene Model | MGI Sequence Detail 1975 C57BL/6J ±  kb
transcript NM_009073 RefSeq | MGI Sequence Detail 1526 C57BL/6  
polypeptide P32958 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    22 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 73
    Genomic 1
    cDNA 71
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14007, MGD-MRK-14008, MGI:3814073
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:2878 Bascom RA, et al., Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM. Am J Hum Genet. 1992 Nov;51(5):1028-35
  • Latest
    J:230346 Omori Y, et al., Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory