Rom1
Gene Detail

Symbol Name ID

Rom1 rod outer segment membrane protein 1 MGI:97998

Synonyms

M101156, Rgsc1156, Rom-1, Tspan23

Feature Type

protein coding gene

Genetic Map

Chromosome 19

6.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:8927382-8929356 bp, - strand From NCBI annotation of GRCm38   1975 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: retinal degeneration slow protein
Gene Tree: Rom1

Human homologs

Human Homolog		ROM1, retinal outer segment membrane protein 1
NCBI Gene ID		6094
neXtProt AC		NX_Q03395
Human Synonyms		ROM, ROSP1, RP7, TSPAN23
Human Chr (Location)		11q13; chr11:62380213-62382592 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ROM1

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Chemically induced(1)
 

Homozygous null mutants exhibit large retinal discs, disorganized outer segments, gradual loss of rod photoreceptors by apoptosis, and diminished photo responses.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cell adhesion, visual perception
Component	integral to membrane, membrane, ...
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 28

Assay Type	Results
Immunohistochemistry	2

cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(1) cDNA(70) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000071648 (Evidence)
Entrez Gene	19881 (Evidence)
UniGene	426094
DFCI	TC1578594
NIA Mouse Gene Index	U038784
Consensus CDS Project	CCDS29559.1
International Mouse Knockout Project Status	Rom1

Sequences

Length	Strain/Species
genomic	19881	NCBI Gene Model | MGI Sequence Detail	1975	C57BL/6J
transcript	NM_009073	RefSeq | MGI Sequence Detail	1526	C57BL/6
polypeptide	P32958	UniProt | EBI | MGI Sequence Detail	351	Not Applicable

All sequences(13) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000830	Peripherin/rom-1
InterPro	IPR018498	Peripherin/rom-1, conserved site
InterPro	IPR008952	Tetraspanin, EC2 domain
InterPro	IPR018499	Tetraspanin/Peripherin
Protein Ontology	PR:000014157	rod outer segment membrane protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:2878 Bascom RA, et al., Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM. Am J Hum Genet. 1992 Nov;51(5):1028-35
(Latest) J:178434 Omori Y, et al., Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22671-6
All references(42)

Other accession IDs

MGD-MRK-14007, MGD-MRK-14008, MGI:3814073