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Rom1
Gene Detail
 Symbol
Name
ID
Rom1
rod outer segment membrane protein 1
MGI:97998
Synonyms M101156, Rgsc1156, Rom-1, Tspan23
Feature Type protein coding gene
Genetic Map
Chromosome 19
6.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8927382-8929356 bp, - strand
From NCBI annotation of GRCm38

  1975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: retinal degeneration slow protein
Gene Tree: Rom1

Human
homologs
Human Homolog ROM1, retinal outer segment membrane protein 1
NCBI Gene ID 6094
neXtProt AC  NX_Q03395
Human Synonyms  ROM, ROSP1, RP7, TSPAN23
Human Chr (Location)  11q13; chr11:62612741-62615120 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ROM1
Alleles
and
phenotypes
All alleles(4) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit large retinal discs, disorganized outer segments, gradual loss of rod photoreceptors by apoptosis, and diminished photo responses.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process camera-type eye photoreceptor cell differentiation, cell adhesion, ...
Component integral component of membrane, membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (2)    Tissues (1)   
Theiler Stages: 28
Assay TypeResults
Immunohistochemistry 2
cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(73) Genomic(1) cDNA(71) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000071648 (Evidence)
Entrez Gene19881 (Evidence)
UniGene426094
DFCITC1578594
NIA Mouse Gene IndexU038784
Consensus CDS ProjectCCDS29559.1
International Mouse Knockout Project StatusRom1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19881 NCBI Gene Model | MGI Sequence Detail 1975 C57BL/6J ±  kb
transcript NM_009073 RefSeq | MGI Sequence Detail 1526 C57BL/6 
polypeptide P32958 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000830 Peripherin/rom-1
InterPro IPR018498 Peripherin/rom-1, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000014157 rod outer segment membrane protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:2878 Bascom RA, et al., Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM. Am J Hum Genet. 1992 Nov;51(5):1028-35
(Latest) J:178434 Omori Y, et al., Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22671-6
All references(42)
Other
accession IDs
MGD-MRK-14007, MGD-MRK-14008, MGI:3814073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory