About   Help   FAQ
Ren2
Gene Detail
Symbol

Name
ID
Ren2
renin 2 tandem duplication of Ren1
MGI:97899
Synonyms
Ren, Ren-2, Ren-B, Rn-2, Rnr
Feature Type
protein coding gene
Genetic Map
Chromosome 1
Syntenic

Mapping data(43)
Vertebrate
homology
Protein SuperFamily: Pepsin
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
 
Mice homozygous for a targeted null mutation are viable and fertile; no defects in the function of the renin-angiotensin system were detected and blood pressure regulation was normal.
 
Interactions
Ren2 interacts with 1 marker (Mir1264)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (48)    Tissues (10)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 37
Northern blot 4
RT-PCR 2
cDNA source data(4)
External Resources: Allen Institute   GEO  
Molecular
reagents
All nucleic(27) Genomic(10) cDNA(15) Primer pair(1) Other(1)
Other database
links
Entrez Gene19702 (Evidence)
DoTSDT.491185
EC3.4.23.15
PDB1SMR
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic K02597 GenBank | EMBL | DDBJ | MGI Sequence Detail 640 Not Specified ±  kb
transcript NM_031193 RefSeq | MGI Sequence Detail 1547 FVB/N 
polypeptide P00796 UniProt | EBI | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(10) : SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR001969 Peptidase aspartic, active site
InterPro IPR012848 Propeptide, peptidase A1
Protein Ontology PR:000014395 renin-2
Graphical View of Protein Domain Structure
References
(Earliest) J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
(Latest) J:175301 Kitazawa T, et al., Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney. Gene Expr Patterns. 2011 Oct;11(7):371-7
All references(79)
Other
accession IDs
MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13835, MGD-MRK-13837, MGD-MRK-13839, MGD-MRK-13918, MGD-MRK-13951

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory