Ren2
Gene Detail

Symbol Name ID

Ren2 renin 2 tandem duplication of Ren1 MGI:97899

Strain-Specific Marker

Synonyms

Ren, Ren-2, Ren-B, Rn-2, Rnr

Feature Type

protein coding gene

Genetic Map

Chromosome 1
Syntenic

Mapping data(43)

Sequence Map

Chr1:133350563-133360322 bp From MGI annotation of GRCm38   9760 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: Pepsin

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a targeted null mutation are viable and fertile; no defects in the function of the renin-angiotensin system were detected and blood pressure regulation was normal.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	metabolic process, positive regulation of blood pressure, ...
Component	extracellular region, extracellular space
Function	aspartic-type endopeptidase activity, endopeptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (48)    Tissues (10)    Images (29)
Theiler Stages: 23, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	37
Northern blot	4
RT-PCR	2

cDNA source data(4)
External Resources: Allen Institute   GEO  

Molecular reagents

All nucleic(27) Genomic(10) cDNA(15) Primer pair(1) Other(1)

Other database links

Entrez Gene	19702 (Evidence)
DoTS	DT.491185
EC	3.4.23.15
PDB	1SMR

Sequences

Length	Strain/Species
genomic	K02597	GenBank | EMBL | DDBJ | MGI Sequence Detail	640	Not Specified
transcript	NM_031193	RefSeq | MGI Sequence Detail	1547	FVB/N
polypeptide	P00796	UniProt | EBI | MGI Sequence Detail	401	Not Applicable

All sequences(12) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(10) : SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021109	Aspartic peptidase
InterPro	IPR001461	Peptidase A1
InterPro	IPR001969	Peptidase aspartic, active site
InterPro	IPR012848	Propeptide, peptidase A1
Protein Ontology	PR:000014395	renin-2

Graphical View of Protein Domain Structure

References

(Earliest) J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
(Latest) J:175301 Kitazawa T, et al., Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney. Gene Expr Patterns. 2011 Oct;11(7):371-7
All references(79)

Other accession IDs

MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13835, MGD-MRK-13837, MGD-MRK-13839, MGD-MRK-13918, MGD-MRK-13951