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Ren2 Gene Detail
Summary
  • Symbol
    Ren2
  • Name
    renin 2 tandem duplication of Ren1
  • Synonyms
    Ren, Ren-2, Ren-B, Rn-2, Rnr
  • Feature Type
    protein coding gene
  • IDs
    MGI:97899
    NCBI Gene: 19702
  • Alliance
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 1, Syntenic
  • Mapping Data
    43 experiments
Strain
Comparison
more
Homology
more
  • Human Ortholog
    REN, renin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REN, renin
  • Synonyms
    ADTKD4, HNFJ2, RTD
  • Links
    NCBI Gene ID: 5972
    neXtProt AC: NX_P00797
    UniProt: P00797

  • Chr Location
    1q32.1; chr1:204154819-204190324 (-)  GRCh38

Human Diseases
more
  • Diseases
    5 with human REN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype reference
Mice homozygous for a targeted null mutation are viable and fertile; no defects in the function of the renin-angiotensin system were detected and blood pressure regulation was normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic K02597 GenBank | ENA | DDBJ | MGI Sequence Detail 640 Not Specified ±  kb
transcript NM_031193 RefSeq | MGI Sequence Detail 1547 FVB/N  
polypeptide P00796 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 29
    Genomic 10
    cDNA 16
    Primer pair 1
    Other 2
Other
Accession IDs
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MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13835, MGD-MRK-13837, MGD-MRK-13839, MGD-MRK-13918, MGD-MRK-13951
References
more
  • Summaries
    All 93
    Developmental Gene Expression 13
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:5794 Wilson CM, et al., Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1185-9
  • Latest
    J:333395 Gunawardhana KL, et al., A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. J Clin Invest. 2023 Feb 15;133(4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory