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Ptprg
Gene Detail
Symbol

Name
ID
Ptprg
protein tyrosine phosphatase, receptor type, G
MGI:97814
Synonyms
5430405N12Rik, RPTPgamma
Feature Type
protein coding gene
Genetic Map
Chromosome 14
6.33 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr14:11553532-12242041 bp, + strand
From VEGA annotation of GRCm38

  688510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2129  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: receptor-type protein-tyrosine phosphatase gamma
Gene Tree: Ptprg

Human
homologs
Human Homolog PTPRG, protein tyrosine phosphatase, receptor type, G
NCBI Gene ID 5793
neXtProt AC  NX_P23470
Human Synonyms  HPTPG, PTPG, RPTPG, R-PTP-GAMMA
Human Chr (Location)  3p21-p14; chr3:61561569-62297609 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(99) : Gene trapped(94) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning.
 
Interactions
Ptprg interacts with 442 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process dephosphorylation, negative regulation of epithelial cell migration, ...
Component extracellular space, extracellular vesicular exosome, ...
Function hydrolase activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (52)    Tissues (37)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 31
Western blot 9
RT-PCR 8
cDNA source data(147)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(153) Genomic(3) cDNA(147) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000029429 (Evidence)
Ensembl Gene ModelENSMUSG00000021745 (Evidence)
Entrez Gene19270 (Evidence)
UniGene431266
DFCITC1579620, TC1587296, TC1602772, TC1614237, TC1686809
DoTSDT.530297, DT.101144441, DT.101236278, DT.101376360, DT.87068333
NIA Mouse Gene IndexU015305
EC3.1.3.48
PDB3JXG, 3KLD
Consensus CDS ProjectCCDS26816.1
International Mouse Knockout Project StatusPtprg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029429 VEGA Gene Model | MGI Sequence Detail 688510 C57BL/6J ±  kb
transcript OTTMUST00000072925 VEGA | MGI Sequence Detail 9213 Not Applicable 
polypeptide OTTMUSP00000037658 VEGA | MGI Sequence Detail 1442 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(7646 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013470 receptor-type tyrosine-protein phosphatase gamma
References
(Earliest) J:4318 Wary KK, et al., A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. Cancer Res. 1993 Apr 1;53(7):1498-502
(Latest) J:197389 Slater LH, et al., CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7
All references(56)
Other
accession IDs
MGD-MRK-13683, MGI:1918574, MGI:2145785, MGI:2145832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory