Ptprg
Gene Detail

Symbol Name ID

Ptprg protein tyrosine phosphatase, receptor type, G MGI:97814

Synonyms

5430405N12Rik, RPTPgamma

Feature Type

protein coding gene

Genetic Map

Chromosome 14

6.33 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr14:11553532-12242041 bp, + strand From VEGA annotation of GRCm38   688510 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2129  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor-type protein-tyrosine phosphatase gamma
Gene Tree: Ptprg

Human homologs

Human Homolog		PTPRG, protein tyrosine phosphatase, receptor type, G
NCBI Gene ID		5793
neXtProt AC		NX_P23470
Human Synonyms		HPTPG, PTPG, RPTPG, R-PTP-GAMMA
Human Chr (Location)		3p21-p14; chr3:61561569-62297609 (+)  GRCh38

Alleles and phenotypes

All alleles(99) : Gene trapped(94) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	dephosphorylation, negative regulation of neuron projection development, ...
Component	extracellular space, extracellular vesicular exosome, ...
Function	hydrolase activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (52)    Tissues (36)    Images (8)
Theiler Stages: 11, 13, 19, 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	31
Western blot	9
RT-PCR	8

cDNA source data(147)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(153) Genomic(3) cDNA(147) Primer pair(2) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000029429 (Evidence)
Ensembl Gene Model	ENSMUSG00000021745 (Evidence)
Entrez Gene	19270 (Evidence)
UniGene	431266
DFCI	TC1579620, TC1587296, TC1602772, TC1614237, TC1686809
DoTS	DT.101144441, DT.101236278, DT.101376360, DT.530297, DT.87068333
NIA Mouse Gene Index	U015305
EC	3.1.3.48
PDB	3JXG, 3KLD
Consensus CDS Project	CCDS26816.1
International Mouse Knockout Project Status	Ptprg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029429	VEGA Gene Model | MGI Sequence Detail	688510	C57BL/6J
transcript	OTTMUST00000072925	VEGA | MGI Sequence Detail	9213	Not Applicable
polypeptide	OTTMUSP00000037658	VEGA | MGI Sequence Detail	1442	Not Applicable

All sequences(60) RefSeq(6) UniProt(7)

Polymorphisms

RFLP(2) : SNPs within 2kb(7646 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013470	receptor-type tyrosine-protein phosphatase gamma

References

(Earliest) J:4318 Wary KK, et al., A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. Cancer Res. 1993 Apr 1;53(7):1498-502
(Latest) J:191998 Zhang W, et al., Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells. PLoS One. 2012;7(9):e45500
All references(55)

Other accession IDs

MGD-MRK-13683, MGI:1918574, MGI:2145785, MGI:2145832