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Ptprg Gene Detail
Summary
  • Symbol
    Ptprg
  • Name
    protein tyrosine phosphatase, receptor type, G
  • Synonyms
    5430405N12Rik, RPTPgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:97814
    NCBI Gene: 19270
  • Gene Overview
    MyGene.info: PTPRG
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:11553532-12242041 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      688510 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 6.33 cM, cytoband A2
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    PTPRG, protein tyrosine phosphatase, receptor type G
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPRG, protein tyrosine phosphatase, receptor type G
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HPTPG, PTPG, RPTPG, R-PTP-GAMMA
  • Links
    NCBI Gene ID: 5793
    neXtProt AC: NX_P23470
    UniProt: P23470

  • Chr Location
    3p14.2; chr3:61561569-62297609 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    52
  • Tissues
    37
  • cDNA Data
    148
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029429 VEGA Gene Model | MGI Sequence Detail 688510 C57BL/6J ±  kb
transcript OTTMUST00000072925 VEGA | MGI Sequence Detail 9213 Not Applicable  
polypeptide OTTMUSP00000037658 VEGA | MGI Sequence Detail 1442 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    7586 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 153
    Genomic 3
    cDNA 148
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-13683, MGI:1918574, MGI:2145785, MGI:2145832
References
more
  • Summaries
    All 52
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:4318 Wary KK, et al., A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. Cancer Res. 1993 Apr 1;53(7):1498-502
  • Latest
    J:237301 Nikolaienko RM, et al., Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J Biol Chem. 2016 Oct 07;291(41):21335-21349
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/18/2018
MGI 6.12 		The Jackson Laboratory