Ptprg MGI Mouse Gene Detail - MGI:97814 - protein tyrosine phosphatase, receptor type, G

Symbol

Ptprg
Name

protein tyrosine phosphatase, receptor type, G
Synonyms

5430405N12Rik, RPTPgamma

Feature Type

protein coding gene
IDs

MGI:97814
NCBI Gene: 19270
Gene Overview

MyGene.info: PTPRG
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:11553532-12242041 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 6.33 cM, cytoband A2
Mapping Data

12 experiments

SNPs within 2kb

7586 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97814	protein coding gene	Chr14:11553440-12242041 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020997	protein coding gene	Chr14:3935401-4672520 (+)
A/J	MGP_AJ_G0020945	protein coding gene	Chr14:3867069-4564250 (+)
AKR/J	MGP_AKRJ_G0020922	protein coding gene	Chr14:3924712-4639456 (+)
BALB/cJ	MGP_BALBcJ_G0020948	protein coding gene	Chr14:3854892-4552325 (+)
C3H/HeJ	MGP_C3HHeJ_G0020732	protein coding gene	Chr14:3970785-4686634 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021381	protein coding gene	Chr14:4072669-4807718 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018950	protein coding gene	Chr14:4612129-5293634 (+)
CAST/EiJ	MGP_CASTEiJ_G0020254	protein coding gene	Chr14:3938254-4677312 (+)
CBA/J	MGP_CBAJ_G0020698	protein coding gene	Chr14:4234190-4982179 (+)
DBA/2J	MGP_DBA2J_G0020821	protein coding gene	Chr14:3822717-4522292 (+)
FVB/NJ	MGP_FVBNJ_G0020803	protein coding gene	Chr14:3780753-4472518 (+)
LP/J	MGP_LPJ_G0020897	protein coding gene	Chr14:3873670-4609225 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020829	protein coding gene	Chr14:4312937-5048359 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021414	protein coding gene	Chr14:3884255-4618114 (+)
PWK/PhJ	MGP_PWKPhJ_G0020006	protein coding gene	Chr14:3820392-4529582 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019826	protein coding gene	Chr14:3985822-4697763 (+)
WSB/EiJ	MGP_WSBEiJ_G0020312	protein coding gene	Chr14:3925823-4658476 (+)

Human Ortholog

PTPRG, protein tyrosine phosphatase receptor type G

Vertebrate Orthologs

10

Human Ortholog

PTPRG, protein tyrosine phosphatase receptor type G
Orthology source: HomoloGene, HGNC
Synonyms

HPTPG, PTPG, RPTPG, R-PTP-GAMMA
Links

HGNC:9671

NCBI Gene ID: 5793

neXtProt AC: NX_P23470

UniProt: P23470
Chr Location

3p14.2; chr3:61561569-62297609 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2129
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PTPRG
Protein SuperFamily

receptor-type protein-tyrosine phosphatase gamma
Gene Tree

Ptprg

less

Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

94
Gene trapped

89
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning.

less

All GO Annotations

16
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

683
Tissues

37
cDNA Data

148
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PTPRG

Xenbase ptprg

less

Ptprg interacts with 442 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

less

All Sequences

60
RefSeq

6
UniProt

8
CCDS

CCDS26816.1, CCDS84092.1
UniGene

431266

Ensembl

ENSMUSG00000021745 (Evidence)
NCBI Gene

19270

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021745	Ensembl Gene Model \| MGI Sequence Detail	688510	C57BL/6J	± kb
transcript	ENSMUST00000022264	Ensembl \| MGI Sequence Detail	9213	Not Applicable
polypeptide	ENSMUSP00000022264	Ensembl \| MGI Sequence Detail	1442	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000013470 receptor-type tyrosine-protein phosphatase gamma

(term hierarchy)
PDB

3JXG, 3KLD, 5E5U
EC

3.1.3.48
InterPro Domains

IPR001148 Alpha carbonic anhydrase domain

IPR036398 Alpha carbonic anhydrase domain superfamily

IPR023561 Carbonic anhydrase, alpha-class

IPR018431 Carbonic anhydrase, CA14

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 PTP type protein phosphatase

IPR041887 Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain

IPR000387 Tyrosine specific protein phosphatases domain

less

All nucleic 153

Genomic 3

cDNA 148

Primer pair 2

Microarray probesets 8

less

MGD-MRK-13683, MGI:1918574, MGI:2145785, MGI:2145832

Summaries

All 56

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 16
Earliest

J:4318 Wary KK, et al., A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. Cancer Res. 1993 Apr 1;53(7):1498-502
Latest

J:298643 Hansen KB, et al., PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion. Elife. 2020 Sep 21;9

TSS for Ptprg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124258	Chr14:11553461-11553484 (+)	-59 bp
Tssr124259	Chr14:11553499-11553514 (+)	-25 bp
Tssr124260	Chr14:11553523-11553542 (+)	1 bp
Tssr124261	Chr14:11553555-11553564 (+)	28 bp
Tssr124262	Chr14:11553568-11553597 (+)	51 bp
Tssr124263	Chr14:11553598-11553615 (+)	75 bp
Tssr124264	Chr14:11553702-11553773 (+)	206 bp
Tssr124277	Chr14:12189948-12189953 (+)	636,419 bp
Tssr124278	Chr14:12189969-12190001 (+)	636,453 bp
Tssr124279	Chr14:12190003-12190025 (+)	636,482 bp
Tssr124280	Chr14:12190042-12190047 (+)	636,513 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16