Ptprg
Gene Detail

Symbol

Name
ID

Ptprg
protein tyrosine phosphatase, receptor type, G
MGI:97814

Synonyms

5430405N12Rik, RPTPgamma

Feature Type

protein coding gene

Genetic Map

Chromosome 14
6.33 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr14:11553532-12242041 bp, + strand From VEGA annotation of GRCm38   688510 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2129  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: receptor-type protein-tyrosine phosphatase gamma
Gene Tree: Ptprg

Human
homologs

Human Homolog		PTPRG, protein tyrosine phosphatase, receptor type, G
NCBI Gene ID		5793
neXtProt AC		NX_P23470
Human Synonyms		HPTPG, PTPG, RPTPG, R-PTP-GAMMA
Human Chr (Location)		3p21-p14; chr3:61561569-62297609 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(99) : Gene trapped(94) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning.

 

Interactions

Ptprg interacts with 442 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (15 annotations)

Process	dephosphorylation, negative regulation of epithelial cell migration, ...
Component	extracellular space, extracellular vesicular exosome, ...
Function	hydrolase activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (52)    Tissues (37)    Images (8)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	4
RNA in situ	31
Western blot	9
RT-PCR	8

cDNA source data(147)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(153) Genomic(3) cDNA(147) Primer pair(2) Other(1)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000029429 (Evidence)
Ensembl Gene Model	ENSMUSG00000021745 (Evidence)
Entrez Gene	19270 (Evidence)
UniGene	431266
DFCI	TC1579620, TC1587296, TC1602772, TC1614237, TC1686809
DoTS	DT.530297, DT.101144441, DT.101236278, DT.101376360, DT.87068333
NIA Mouse Gene Index	U015305
EC	3.1.3.48
PDB	3JXG, 3KLD
Consensus CDS Project	CCDS26816.1
International Mouse Knockout Project Status	Ptprg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029429	VEGA Gene Model | MGI Sequence Detail	688510	C57BL/6J
transcript	OTTMUST00000072925	VEGA | MGI Sequence Detail	9213	Not Applicable
polypeptide	OTTMUSP00000037658	VEGA | MGI Sequence Detail	1442	Not Applicable

All sequences(66) RefSeq(6) UniProt(13)

Polymorphisms

RFLP(2) : SNPs within 2kb(7646 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000387	Protein-tyrosine/Dual specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013470	receptor-type tyrosine-protein phosphatase gamma

References

(Earliest) J:4318 Wary KK, et al., A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. Cancer Res. 1993 Apr 1;53(7):1498-502
(Latest) J:197389 Slater LH, et al., CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7
All references(56)

Other
accession IDs

MGD-MRK-13683, MGI:1918574, MGI:2145785, MGI:2145832