About   Help   FAQ
Ctsa
Gene Detail
 Symbol
Name
ID
Ctsa
cathepsin A
MGI:97748
Synonyms PPCA, Ppgb
Feature Type protein coding gene
Genetic Map
Chromosome 2
85.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:164832873-164841032 bp, + strand
From VEGA annotation of GRCm38

  8160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine carboxypeptidase
Gene Tree: Ctsa

Human
homologs
Human Homolog CTSA, cathepsin A
NCBI Gene ID 5476
neXtProt AC  NX_P10619
Human Synonyms  GLB2, GSL, NGBE, PPCA, PPGB
Human Chr (Location)  20q13.1; chr20:45890952-45898820 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTSA
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(5) Targeted(7)
Incidental mutations (data from APF )
 
Homozygous mutants show aberrant lysosomal storage, with vacuolization in specific cells of most tissues. An abormally flat face and reduced body size are apparent at birth, and health progressively deteriorates, with accompanying generalized edema, ataxia and tremors. Death occurs at ~12 months.
 
Human Diseases Modeled Using Mouse Ctsa (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ctsa interacts with 212 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process proteolysis
Component extracellular vesicular exosome, intracellular membrane-bounded organelle, ...
Function carboxypeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (103)    Tissues (97)    Images (9)
Theiler Stages: 22, 25, 26, 28
Assay TypeResults
RNA in situ 94
RT-PCR 9
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001170 (Evidence)
Ensembl Gene ModelENSMUSG00000017760 (Evidence)
Entrez Gene19025 (Evidence)
DFCITC1573370, TC1605445, TC1614027
NIA Mouse Gene IndexU002821
EC3.4.16.5
Consensus CDS ProjectCCDS17061.1, CCDS17062.1
International Mouse Knockout Project StatusCtsa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001170 VEGA Gene Model | MGI Sequence Detail 8160 C57BL/6J ±  kb
transcript OTTMUST00000002280 VEGA | MGI Sequence Detail 2534 Not Applicable 
polypeptide OTTMUSP00000001116 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(4) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001563 Peptidase S10, serine carboxypeptidase
InterPro IPR018202 Peptidase S10, serine carboxypeptidase, active site
Protein Ontology PR:000006022 lysosomal protective protein
References (Earliest) J:10347 Galjart NJ, et al., Mouse protective protein. cDNA cloning, sequence comparison, and expression. J Biol Chem. 1990 Mar 15;265(8):4678-84
(Latest) J:211006 Pan X, et al., Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1. PLoS Genet. 2014 Feb;10(2):e1004146
All references(49)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13590, MGI:2139179

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory