Plcg2
Gene Detail

Symbol Name ID

Plcg2 phospholipase C, gamma 2 MGI:97616

Synonyms

MGC:38590, Plcg-2, PLCgamma2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

64.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:117498291-117635140 bp, + strand From Ensembl annotation of GRCm38   136850 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55671  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma
Gene Tree: Plcg2

Human homologs

Human Homolog		PLCG2, phospholipase C, gamma 2 (phosphatidylinositol-specific)
NCBI Gene ID		5336
neXtProt AC		NX_P16885
Human Synonyms		APLAID, FCAS3
Human Chr (Location)		16q24.1; chr16:81812899-81991899 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PLCG2

Alleles and phenotypes

All alleles(20) : Targeted(6) Gene trapped(10) Spontaneous(1) Chemically induced(3)
 

Homozygotes for some null alleles show decreased B cell and impaired NK cell function. Other homozygous null alleles show aberrant separation of blood and lymphatic vessels.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	activation of store-operated calcium channel activity, B cell differentiation, ...
Component	cytosol, membrane, ...
Function	hydrolase activity, phosphatidylinositol phospholipase C activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (285)    Tissues (124)    Images (30)
Theiler Stages: 2, 22, 23

Assay Type	Results
RNA in situ	284
RT-PCR	1

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(14) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000034330 (Evidence)
Entrez Gene	234779 (Evidence)
DFCI	TC1575936
DoTS	DT.528124
NIA Mouse Gene Index	U009868
EC	3.1.4.11
PDB	2EQI, 2DX0
Consensus CDS Project	CCDS22700.1
International Mouse Knockout Project Status	Plcg2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000034330	Ensembl Gene Model | MGI Sequence Detail	136850	C57BL/6J
transcript	ENSMUST00000081232	Ensembl | MGI Sequence Detail	4296	Not Applicable
polypeptide	ENSMUSP00000079991	Ensembl | MGI Sequence Detail	1265	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(3) : SNPs(491 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR016279	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
InterPro	IPR001192	Phosphoinositide phospholipase C
InterPro	IPR000909	Phospholipase C, phosphatidylinositol-specific , X domain
InterPro	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro	IPR015359	Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000012837	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

References

(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:189870 Fu G, et al., Phospholipase Cgamma2 plays a role in TCR signal transduction and T cell selection. J Immunol. 2012 Sep 1;189(5):2326-32
All references(108)

Other accession IDs

MGD-MRK-13354, MGD-MRK-13356