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Plcg2
Gene Detail
 Symbol
Name
ID
Plcg2
phospholipase C, gamma 2
MGI:97616
Synonyms MGC:38590, Plcg-2, PLCgamma2
Feature Type protein coding gene
Genetic Map
Chromosome 8
64.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:117498291-117635140 bp, + strand
From Ensembl annotation of GRCm38

  136850 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55671  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma
Gene Tree: Plcg2

Human
homologs
Human Homolog PLCG2, phospholipase C, gamma 2 (phosphatidylinositol-specific)
NCBI Gene ID 5336
neXtProt AC  NX_P16885
Human Synonyms  APLAID, FCAS3, PLC-gamma-2, PLC-IV
Human Chr (Location)  16q24.1; chr16:81779294-81958294 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PLCG2
Alleles
and
phenotypes
All alleles(20) : Chemically induced (ENU)(3) Gene trapped(10) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for some null alleles show decreased B cell and impaired NK cell function. Other homozygous null alleles show aberrant separation of blood and lymphatic vessels.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process activation of store-operated calcium channel activity, B cell differentiation, ...
Component cytosol, extracellular vesicular exosome, ...
Function hydrolase activity, phosphatidylinositol phospholipase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (285)    Tissues (124)    Images (30)
Theiler Stages: 2, 22, 23
Assay TypeResults
RNA in situ 284
RT-PCR 1
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000034330 (Evidence)
Entrez Gene234779 (Evidence)
DFCITC1575936
DoTSDT.528124
NIA Mouse Gene IndexU009868
EC3.1.4.11
PDB2EQI, 2DX0
Consensus CDS ProjectCCDS22700.1
International Mouse Knockout Project StatusPlcg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034330 Ensembl Gene Model | MGI Sequence Detail 136850 C57BL/6J ±  kb
transcript ENSMUST00000081232 Ensembl | MGI Sequence Detail 4296 Not Applicable 
polypeptide ENSMUSP00000079991 Ensembl | MGI Sequence Detail 1265 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms RFLP(3) : SNPs within 2kb(521 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000012837 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
References (Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:206537 Capietto AH, et al., Down-regulation of PLCgamma2-beta-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. J Exp Med. 2013 Oct 21;210(11):2257-71
All references(110)
Other
accession IDs
MGD-MRK-13354, MGD-MRK-13356

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory