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Pdha2
Gene Detail
Symbol

Name
ID
Pdha2
pyruvate dehydrogenase E1 alpha 2
MGI:97533
Synonyms
Pdhal
Feature Type
protein coding gene
Genetic Map
Chromosome 3
65.30 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:141210004-141212355 bp, - strand
From NCBI annotation of GRCm38

  2352 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:137212  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: PDHA2
Protein SuperFamily: pyruvate dehydrogenase (lipoamide) alpha chain
Gene Tree: Pdha2

Human
homologs
PDHA2, pyruvate dehydrogenase (lipoamide) alpha 2
Orthology source: HGNC

IDs:
NCBI Gene ID: 5161
neXtProt AC: NX_P29803

Human Synonyms: PDHAL

Human Chr (Location): 4q22-q23; chr4:95840088-95841474 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pdha2 interacts with 70 markers (Mir7-1, Mir10a, Mir32, ...)
Expression
Literature Summary: (2 records)
Data Summary: Results (196)    Tissues (102)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
RT-PCR 8
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(17) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000047674 (Evidence)
Entrez Gene 18598 (Evidence)
UniGene 4223
DFCI TC1584182
DoTS DT.40158073
NIA Mouse Gene Index U024709
EC 1.2.4.1
Consensus CDS Project CCDS17872.1
International Mouse Phenotyping Consortium Status Pdha2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18598 NCBI Gene Model | MGI Sequence Detail 2352 C57BL/6J ±  kb
transcript NM_008811 RefSeq | MGI Sequence Detail 2352 C57BL/6 
polypeptide P35487 UniProt | EBI | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001017 Dehydrogenase, E1 component
InterPro IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
Protein Ontology PR:000012494 pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:10821 Brown RM, et al., Pyruvate dehydrogenase E1 alpha subunit genes in the mouse: mapping and comparison with human homologs. Somat Cell Mol Genet. 1990 Sep;16(5):487-92
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGD-MRK-13220

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory