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Pdha2
Gene Detail
 Symbol
Name
ID
Pdha2
pyruvate dehydrogenase E1 alpha 2
MGI:97533
Synonyms Pdhal
Feature Type protein coding gene
Genetic Map
Chromosome 3
65.30 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:141210004-141212355 bp, - strand
From NCBI annotation of GRCm38

  2352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: pyruvate dehydrogenase (lipoamide) alpha chain
Gene Tree: Pdha2

Human
homologs
Human Homolog PDHA2, pyruvate dehydrogenase (lipoamide) alpha 2
NCBI Gene ID 5161
neXtProt AC  NX_P29803
Human Synonyms  PDHAL
Human Chr (Location)  4q22-q23; chr4:95840088-95841474 (+)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process acetyl-CoA biosynthetic process from pyruvate, carbohydrate metabolic process, ...
Component intracellular membrane-bounded organelle, mitochondrion, ...
Function oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (196)    Tissues (102)    Images (4)
Theiler Stages: 15, 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 188
RT-PCR 8
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(2) cDNA(17) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000047674 (Evidence)
Entrez Gene18598 (Evidence)
UniGene4223
DFCITC1584182
DoTSDT.40158073
NIA Mouse Gene IndexU024709
EC1.2.4.1
Consensus CDS ProjectCCDS17872.1
International Mouse Knockout Project StatusPdha2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18598 NCBI Gene Model | MGI Sequence Detail 2352 C57BL/6J ±  kb
transcript NM_008811 RefSeq | MGI Sequence Detail 2352 C57BL/6 
polypeptide P35487 UniProt | EBI | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001017 Dehydrogenase, E1 component
InterPro IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
Protein Ontology PR:000012494 pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:10821 Brown RM, et al., Pyruvate dehydrogenase E1 alpha subunit genes in the mouse: mapping and comparison with human homologs. Somat Cell Mol Genet. 1990 Sep;16(5):487-92
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGD-MRK-13220

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory