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Pde6a
Gene Detail
 Symbol
Name
ID
Pde6a
phosphodiesterase 6A, cGMP-specific, rod, alpha
MGI:97524
Synonyms Pdea
Feature Type protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr18:61220482-61289924 bp, + strand
From VEGA annotation of GRCm38

  69443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:380  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-GMP phosphodiesterase alpha chain
Gene Tree: Pde6a

Human
homologs
Human Homolog PDE6A, phosphodiesterase 6A, cGMP-specific, rod, alpha
NCBI Gene ID 5145
neXtProt AC  NX_P16499
Human Synonyms  CGPR-A, PDEA, RP43
Human Chr (Location)  5q31.2-q34; chr5:149857956-149944793 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDE6A
Alleles
and
phenotypes
All alleles(5) : Gene trapped(3) Chemically induced(2)
 
Homozygous mutant mice have retinal degeneration.
 
Human Diseases Modeled Using Mouse Pde6a (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cytosolic calcium ion homeostasis, GMP metabolic process, ...
Component membrane, plasma membrane
Function 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (21)    Tissues (8)    Images (2)
Theiler Stages: 15, 17, 19, 20, 21, 22, 28
Assay TypeResults
RNA in situ 2
RT-PCR 19
cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(65) cDNA(62) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028119 (Evidence)
Ensembl Gene ModelENSMUSG00000024575 (Evidence)
Entrez Gene225600 (Evidence)
UniGene391106
DFCITC1581554, TC1617311
DoTSDT.101713042, DT.110778031, DT.87039666, DT.91408295
NIA Mouse Gene IndexU018790
EC3.1.4.35
Consensus CDS ProjectCCDS29283.1
International Mouse Knockout Project StatusPde6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028119 VEGA Gene Model | MGI Sequence Detail 69443 C57BL/6J ±  kb
transcript OTTMUST00000069637 VEGA | MGI Sequence Detail 4421 Not Applicable 
polypeptide OTTMUSP00000035390 VEGA | MGI Sequence Detail 860 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(5)
Polymorphisms RFLP(4) : SNPs within 2kb(542 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012478 rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
References (Earliest) J:24992 Ovchinnikov YuA, et al., Cyclic GMP phosphodiesterase from cattle retina. Amino acid sequence of the gamma-subunit and nucleotide sequence of the corresponding cDNA. FEBS Lett. 1986 Aug 18;204(2):288-92
(Latest) J:191119 Wert KJ, et al., Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet. 2013 Feb 1;22(3):558-67
All references(47)
Other
accession IDs
MGD-MRK-13208, MGI:3611305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory