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Pax2
Gene Detail
Symbol

Name
ID
Pax2
paired box 2
MGI:97486
Synonyms
Opdc, Pax-2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr19:44756045-44837851 bp, + strand
From VEGA annotation of GRCm38

  81807 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2968  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: PAX2
Protein SuperFamily: paired box protein PAX
Gene Tree: Pax2

Human
homologs
PAX2, paired box 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5076
neXtProt AC: NX_Q02962

Human Synonyms: FSGS7, PAPRS

Human Chr (Location): 10q24; chr10:100735709-100829941 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human PAX2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Chemically induced (ENU)(2) Gene trapped(12) Spontaneous(1) Targeted(7) Transgenic(1)
Genomic Mutations involving Pax2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous targeted and spontaneous null mutants show impaired to absent development of optic nerve, retina, kidney, ureters, genital tracts, inner ear and midhindbrain. Heterozygotes show milder defects of the optic nerve, retina and kidney.
 
Human Diseases Modeled in Mice Using Pax2 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(3)
Interactions
Pax2 interacts with 201 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (511 records)
Data Summary: Results (985)    Tissues (416)    Images (400)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 147
RNA in situ 701
In situ reporter (knock in) 17
Northern blot 16
Western blot 6
RT-PCR 47
RNase protection 51
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PAX2 ; Xenbase pax2 ; ZFIN pax2a, pax2b    NEW 
Molecular
reagents
All nucleic(52) cDNA(24) Primer pair(5) Other(23)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037630 (Evidence)
Ensembl Gene Model ENSMUSG00000004231 (Evidence)
Entrez Gene 18504 (Evidence)
UniGene 192158
DFCI TC1644020, TC1726614
DoTS DT.91377527, DT.91399396
NIA Mouse Gene Index U019493, U046604
Consensus CDS Project CCDS37998.2
International Mouse Phenotyping Consortium Status Pax2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037630 VEGA Gene Model | MGI Sequence Detail 81807 C57BL/6J ±  kb
transcript OTTMUST00000097085 VEGA | MGI Sequence Detail 4358 Not Applicable 
polypeptide OTTMUSP00000054369 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(24) UniProt(3)
Polymorphisms
RFLP(10) : SNPs within 2kb(489 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR022130 Paired-box protein 2 C-terminal
InterPro IPR001523 Paired domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012315 paired box protein Pax-2
References
(Earliest) J:12104 Dressler GR, et al., Murine genes with homology to Drosophila segmentation genes. Development. 1988;104 Suppl:181-6
(Latest) J:219797 Ranghini EJ, et al., Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
All references(598)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-13145, MGD-MRK-13154, MGI:1934619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory